Results 331 to 340 of about 1,125,892 (364)

Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta.

Science, 1998
Control of stability of beta-catenin is central in the wnt signaling pathway. Here, the protein conductin was found to form a complex with both beta-catenin and the tumor suppressor gene product adenomatous polyposis coli (APC).
Jergen Behrens, B. Jerchow, Martin Wertele, Jan Grimm, C. Asbrand, R. Wirtz, Michael Kehl, D. Wedlich, W. Birchmeier   +8 more
semanticscholar   +1 more source

Association of the APC gene product with beta-catenin.

Science, 1993
Mutations in the human APC gene are linked to familial adenomatous polyposis and to the progression of sporadic colorectal and gastric tumors. To gain insight into APC function, APC-associated proteins were identified by immunoprecipitation experiments ...
B. Rubinfeld, B. Souza, I. Albert, O. Müller, S. Chamberlain, F. Masiarz, S. Munemitsu, P. Polakis   +7 more
semanticscholar   +1 more source

Beta-Catenin and the Survival of Hepatocytes

2017
The Wnt/β-catenin pathway is critical for liver development, differentiation, metabolism, and homeostasis. Aberrations in this pathway have also been identified in many pathophysiological conditions, such as nonalcoholic steatohepatitis, fibrosis, and hepatobiliary neoplasias.
Kari Nejak-Bowen, Satdarshan P.S. Monga
openaire   +2 more sources

Adenoid ameloblastoma harbors beta-catenin mutations

Modern Pathology, 2022
Adenoid ameloblastoma is a very rare benign epithelial odontogenic tumor characterized microscopically by epithelium resembling conventional ameloblastoma, with additional duct-like structures, epithelial whorls, and cribriform architecture. Dentinoid deposits, clusters of clear cells, and ghost-cell keratinization may also be present.
Victor Coutinho Bastos, Bruna Pizziolo Coura, Letícia Martins Guimarães, Bianca Gomes Fernandes, Alexander Chak-Lam Chan, Pablo Agustin Vargas, Luciana Bastos-Rodrigues, Luiz Armando De Marco, John Hellstein, Selvam Thavaraj, John M. Wright, Edward William Odell, Ricardo Santiago Gomez, Carolina Cavaliéri Gomes   +13 more
openaire   +3 more sources

Beta Catenin in Prostate Cancer Apoptosis [PDF]

, 2011
Abstract : During this funding period, we performed TRAIL-TZD-mediated apoptotic studies in androgen dependent (LNCaP and 22RV1) and androgen independent (DU145 and PC3) prostate cancer cells and the response was maximal in the LNCaP cells with 50 M TZD and 100ng/ml TRAIL combination.
openaire   +1 more source

IKK and (Beta)-Catenin in Breast Cancer [PDF]

, 2002
Abstract : The wnt signaling pathway activates oncogene, beta-catenin. It associates with an APC, GSK-3b and axin complex which targets it for phosphorylation and ubiquitin-mediated degradation. NFkB transcription factor is associated with inhibitory IkBa.
openaire   +1 more source

P53 and Beta-Catenin in Colorectal Cancer Progression

Current Pharmaceutical Design, 2003
Recently a possible cross talk about the relationship between p53 and beta-catenin has been suggested by the observation that colorectal cancers accumulating beta-catenin (as a result of APC mutations) also exhibit high frequency p53 mutations. Our aim was to evaluate the pattern of both the proteins and match these with the morphological changes in ...
M. Pirrelli, Anna Maria Valentini, Letizia Renna, Maria Lucia Caruso, Raffaele Armentano   +4 more
openaire   +3 more sources

Beta‐catenin and axis formation in planarians

BioEssays, 2009
AbstractIn three recent articles it was shown that β‐catenin is crucial for the establishment and the maintenance of the overall polarity and especially for the character ‘posterior’ in planarians. If the transcription of the β‐catenin gene was silenced by RNA interference, the overall polarity is lost, and in regenerating fragments a posterior ...
openaire   +2 more sources

beta-catenin-cell adhesion and beyond (review)

International Journal of Oncology, 1997
beta-catenin was originally identified as a cytosolic cell protein required for the correct function of the cadherin cell-cell adhesion complex. However, recent studies have identified the presence of intracellular pools of beta-catenin that are cadherin-independent and that beta-catenin is also involved in Wnt-1, src and Tcf-Lef mediated intracellular
Stephen Edward Hiscox, Wen Guo Jiang
openaire   +3 more sources

Beta-catenin is not activated by downregulation of PTEN in osteoblasts

In Vitro Cellular & Developmental Biology - Animal, 2009
Selective knockdown of phosphatase and tensin homolog (PTEN) has been recently shown to increase life long accumulation of bone and its ability to increase osteoblast lifespan. In order to determine how loss of PTEN function affects osteoblast differentiation, we created cell lines with stable knockdown of PTEN expression using short hairpin RNA ...
Jaime Schmidt, Emily Hays, Nalini Chandar   +2 more
openaire   +3 more sources