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Neurological complications of beta-thalassemia
Annals of Hematology, 2015The thalassemias are the most common single gene disorder in the world. Over the last years, several reports have demonstrated neurological complications in beta-thalassemia patients. In most cases, these complications remained subclinical and were detected only during neuropsychological, neurophysiological, or neuroimaging evaluation.
P. Nemtsas +4 more
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The Silent Carrier of Beta Thalassemia
New England Journal of Medicine, 1969Abstract A family of Albanian descent had an unusual form of beta thalassemia. The father of two children with mild thalassemia major had normal red-cell morphology and normal levels of hemoglobins A2 and F, whereas the mother had elevated hemoglobin A2.
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Beta-Thalassemia Syndromes and Pregnancy
Obstetrical & Gynecological Survey, 1994The literature relating to homozygous beta-thalassemia and the problems these patients have during their pregnancy is reviewed and another case report of a twin pregnancy in a homozygous beta-thalassemia individual is included. The majority of cases described refer to the intermedia clinical form of the hematological problem because patients with ...
Charles Savona-Ventura, F. Bonello
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Gene addition for beta thalassemia
Annals of the New York Academy of Sciences, 2023AbstractIndividuals with transfusion‐dependent beta thalassemia require a high burden of care and experience significant morbidity from the underlying disease and its treatment, which negatively impact the quality of life. Allogeneic hematopoietic stem cell transplantation offers the chance for a cure, but donor availability and transplant‐related ...
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Hematology/Oncology Clinics of North America, 2019
Beta thalassemias are a significant global health problem. Globin chain imbalance leads to a complex physiologic cascade of hemolytic anemia, ineffective erythropoiesis, and iron overload. Management of the broad spectrum of phenotypes requires the careful use of red blood transfusions, supportive care, monitoring, and management of iron overload.
Janet L. Kwiatkowski +2 more
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Beta thalassemias are a significant global health problem. Globin chain imbalance leads to a complex physiologic cascade of hemolytic anemia, ineffective erythropoiesis, and iron overload. Management of the broad spectrum of phenotypes requires the careful use of red blood transfusions, supportive care, monitoring, and management of iron overload.
Janet L. Kwiatkowski +2 more
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Cognitive deficits in beta-thalassemia major
Acta Neurologica Scandinavica, 2000To assess cognitive functioning in patients affected by beta-thalassemia major (beta-th) by using a neuropsychological battery, and to identify clinical correlates.Forty-six beta-th patients and 46 controls similar for age, sex, and education participated in the study. All subjects performed a comprehensive neuropsychological battery including tests of
Roberto Monastero +4 more
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Schizophrenia and beta-thalassemia: A genetic link?
Psychiatry Research, 2008This report of two cases in which schizophrenia and beta-thalassemia occurred simultaneously in several family members may suggest that a genetic link exists between these two disorders. A known genetic disease (beta-thalassemia) could help confirm the presence, on the short arm of chromosome 11, of a genetic susceptibility factor for schizophrenia.
Borras, Laurence, Huguelet, Philippe
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Klinische Pädiatrie, 1999
At present, about 300 patients with thalassemia major are living in Germany. Starting in 1991, a multicenter study in Germany has concentrated on identifying all patients suffering from thalassemia as well as on establishing a uniform therapy protocol including follow-up diagnostic procedures.
Holger Cario +2 more
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At present, about 300 patients with thalassemia major are living in Germany. Starting in 1991, a multicenter study in Germany has concentrated on identifying all patients suffering from thalassemia as well as on establishing a uniform therapy protocol including follow-up diagnostic procedures.
Holger Cario +2 more
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Management of beta‐thalassemia–associated osteoporosis
Annals of the New York Academy of Sciences, 2016Beta‐Thalassemia–associated osteoporosis is a multifactorial and complex condition. Different acquired and genetic factors are involved in its pathogenesis. These factors produce an imbalance in bone remodeling by inhibiting osteoblast activity and increasing osteoclast function, leading to bone loss and increased fracture risk.
Giusti A. +3 more
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Scientific Journal of Medical Research, 2017