Results 301 to 310 of about 1,010,620 (323)
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Gene addition for beta thalassemia
Annals of the New York Academy of Sciences, 2023AbstractIndividuals with transfusion‐dependent beta thalassemia require a high burden of care and experience significant morbidity from the underlying disease and its treatment, which negatively impact the quality of life. Allogeneic hematopoietic stem cell transplantation offers the chance for a cure, but donor availability and transplant‐related ...
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Management of beta‐thalassemia–associated osteoporosis
Annals of the New York Academy of Sciences, 2016Beta‐Thalassemia–associated osteoporosis is a multifactorial and complex condition. Different acquired and genetic factors are involved in its pathogenesis. These factors produce an imbalance in bone remodeling by inhibiting osteoblast activity and increasing osteoclast function, leading to bone loss and increased fracture risk.
A. Giusti +3 more
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Hematology/Oncology Clinics of North America, 2019
Beta thalassemias are a significant global health problem. Globin chain imbalance leads to a complex physiologic cascade of hemolytic anemia, ineffective erythropoiesis, and iron overload. Management of the broad spectrum of phenotypes requires the careful use of red blood transfusions, supportive care, monitoring, and management of iron overload.
Janet L. Kwiatkowski +2 more
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Beta thalassemias are a significant global health problem. Globin chain imbalance leads to a complex physiologic cascade of hemolytic anemia, ineffective erythropoiesis, and iron overload. Management of the broad spectrum of phenotypes requires the careful use of red blood transfusions, supportive care, monitoring, and management of iron overload.
Janet L. Kwiatkowski +2 more
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Cognitive deficits in beta-thalassemia major
Acta Neurologica Scandinavica, 2000To assess cognitive functioning in patients affected by beta-thalassemia major (beta-th) by using a neuropsychological battery, and to identify clinical correlates.Forty-six beta-th patients and 46 controls similar for age, sex, and education participated in the study. All subjects performed a comprehensive neuropsychological battery including tests of
Roberto Monastero +4 more
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Schizophrenia and beta-thalassemia: A genetic link?
Psychiatry Research, 2008This report of two cases in which schizophrenia and beta-thalassemia occurred simultaneously in several family members may suggest that a genetic link exists between these two disorders. A known genetic disease (beta-thalassemia) could help confirm the presence, on the short arm of chromosome 11, of a genetic susceptibility factor for schizophrenia.
Borras, Laurence, Huguelet, Philippe
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, 2016
Background The chronic genetic blood disorder, thalassemia, affects Quality of life (QOL) negatively. Regarding this, if adolescences with thalassemia are treated well, they will grow into an adult who will have a good potential for participating in ...
Shahram Baraz +2 more
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Background The chronic genetic blood disorder, thalassemia, affects Quality of life (QOL) negatively. Regarding this, if adolescences with thalassemia are treated well, they will grow into an adult who will have a good potential for participating in ...
Shahram Baraz +2 more
semanticscholar +1 more source
Klinische Pädiatrie, 1999
At present, about 300 patients with thalassemia major are living in Germany. Starting in 1991, a multicenter study in Germany has concentrated on identifying all patients suffering from thalassemia as well as on establishing a uniform therapy protocol including follow-up diagnostic procedures.
Holger Cario +2 more
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At present, about 300 patients with thalassemia major are living in Germany. Starting in 1991, a multicenter study in Germany has concentrated on identifying all patients suffering from thalassemia as well as on establishing a uniform therapy protocol including follow-up diagnostic procedures.
Holger Cario +2 more
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Exploration of Host Genetic Factors associated with Malaria, 2021
T. Qidwai
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T. Qidwai
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Scientific Journal of Medical Research, 2017 In Brief: Casgevy for Beta Thalassemia
The Medical Letter on Drugs and TherapeuticsExagamglogene autotemcel (Casgevy – Vertex), a cell-based gene therapy recently approved for treatment of sickle cell disease1, has now been approved by the FDA for treatment of patients ≥12 years old with transfusion-dependent beta thalassemia.
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