Results 211 to 220 of about 4,074,440 (299)

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Comparative analysis of anti-MICA scFv affinities: Insights from three label-free biophysical methods and biological validation. [PDF]

Biotechnol Rep (Amst)
Toledo-Stuardo K, Fehring N, Gómez-Velasco H, Sierpe R, Guerra D, Matthies DJ, Guerra Y, González-Herrera F, González M, Campos I, Tello S, Garrido MJ, Vásquez G, Rodríguez-Siza J, Vergara M, Ribeiro CH, Zapata-Torres G, Bollo S, García-Hernández E, Fuentealba D, Valdez-Cruz NA, Altamirano C, Molina MC.   +22 more
europepmc   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

Quantitative Electroencephalography Analysis in Panic Disorder: Exploring the Neurophysiological Significance of High Beta Activity. [PDF]

Psychiatry Investig
Park CH, Lee JY, Jung HY, Lee SI, Oh S, Choi JS, Jang JH, Yoo SY.   +7 more
europepmc   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Volitional modulation of beta-band EMG coherence through frequency-specific neurofeedback. [PDF]

Sci Rep
Nojima I, Horiuchi Y, Yaguchi-Horiuchi A, Tsuji T, Kanazawa H, Yamanaka E.   +5 more
europepmc   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Association between targeted inflammatory proteomics and insulin sensitivity as well as beta-cell function in subjects with normal glucose tolerance. [PDF]

J Mol Cell Biol
Chen A, Li Q, Mao H, Lu Y, Liu D, Zhang L, Fang Q, Wang C, Li H, Jia W.   +9 more
europepmc   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Comparison of SARS-CoV-2 variant pathogenicity in a long-COVID Syrian hamster model. [PDF]

Virus Res
Naghibosadat M, Hahn E, Molinaro S, Babuadze G, Kozak R.   +4 more
europepmc   +1 more source