Results 251 to 260 of about 60,329 (293)

Beta adrenergic signaling as a therapeutic target for autoimmunity. [PDF]

open access: yesJ Neuroimmunol
Lauten TH   +6 more
europepmc   +1 more source

The β-adrenergic receptor kinase in heart failure

Journal of Molecular and Cellular Cardiology, 2003
Heart failure (HF) remains a significant and increasing cause of worldwide morbidity and mortality. HF is less a disease than a common clinical endpoint resulting from diverse, but often co-existing etiologies-including hypertension, coronary artery disease, and viral cardiomyopathy.
Jason A, Petrofski, Walter J, Koch
openaire   +2 more sources

Phosphorylation of chick heart muscarinic cholinergic receptors by the .beta.-adrenergic receptor kinase

Biochemistry, 1989
Previous studies have demonstrated that muscarinic cholinergic receptors (mAChR) become markedly phosphorylated when intact cardiac cells are stimulated with a muscarinic agonist. This process appears to be related to the process of receptor desensitization. However, the mechanism of agonist-induced phosphorylation of mAChR is not known.
M M, Kwatra   +4 more
openaire   +2 more sources

Desensitization of the isolated .beta.2-adrenergic receptor by .beta.-adrenergic receptor kinase, cAMP-dependent protein kinase, and protein kinase C occurs via distinct molecular mechanisms

Biochemistry, 1992
Exposure of beta 2-adrenergic receptors (beta 2ARs) to agonists causes a rapid desensitization of the receptor-stimulated adenylyl cyclase response. Phosphorylation of the beta 2AR by several distinct kinases plays an important role in this desensitization phenomenon.
J, Pitcher   +4 more
openaire   +2 more sources

Activation of β-Adrenergic Receptor Kinase During Myocardial Ischemia

Circulation Research, 1996
During myocardial ischemia, a local release of noradrenaline coincides with an increased density of β-adrenergic receptors. The functional activity of these receptors, however, is mainly determined by their state of phosphorylation. The β-adrenergic receptor kinase (βARK) specifically phosphorylates and thereby inactivates β-adrenergic receptors after ...
M, Ungerer   +4 more
openaire   +2 more sources

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