Results 261 to 270 of about 88,568 (304)

β-Blockers Influence Oncological Outcomes in Gastric Cancer Patients Treated with Neoadjuvant Chemotherapy Based on the Pathological Subtype: A Retrospective Cohort Study. [PDF]

Ann Surg Oncol
Crnovrsanin N, Zumsande S, Rompen IF, Schiefer S, Zimmer S, Hu W, Arnscheidt J, Brinkmann F, Longerich T, Haag GM, Schmidt T, Al-Saeedi M, Sisic L, Nienhüser H.   +13 more
europepmc   +1 more source

Global Sensitivity Analysis of a Novel Signaling Network for Heart Growth With Local IGF1 Production. [PDF]

Int J Numer Method Biomed Eng
Bilas C, Kratzer C, Hinrichs A, Maier A, Wildhirt S, Wolf E, Gee MW.   +6 more
europepmc   +1 more source

Cardiac cGMP Regulation and Therapeutic Applications. [PDF]

Hypertension
Mishra S, Chander V, Kass DA.
europepmc   +1 more source

Role of acidic amino acids in peptide substrates of the .beta.-adrenergic receptor kinase and rhodopsin kinase [PDF]

Biochemistry, 1991
The beta-adrenergic receptor kinase (beta-ARK) phosphorylates G protein coupled receptors in an agonist-dependent manner. Since the exact sites of receptor phosphorylation by beta-ARK are poorly defined, the identification of substrate amino acids that are critical to phosphorylation by the kinase are also unknown.
John W. Regan, Marc G. Caron, James J. Onorato, J. L. Benovic, Robert J. Lefkowitz, Krzysztof Palczewski   +5 more
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Cardiac Function in Mice Overexpressing the β-Adrenergic Receptor Kinase or a βARK Inhibitor

Science, 1995
Transgenic mice were created with cardiac-specific overexpression of the β-adrenergic receptor kinase-1 (βARK1) or a βARK inhibitor. Animals overexpressing βARK1 demonstrated attenuation of isoproterenol-stimulated left ventricular contractility in vivo, dampening of myocardial adenylyl cyclase activity, and reduced functional coupling of β-adrenergic ...
Carmelo A. Milano, Robert J. Lefkowitz, Howard A. Rockman, Walter J. Koch, Richard A. Bond, RaeAnn Hamilton, Philippe Samama   +6 more
openaire   +3 more sources

Desensitization of the isolated .beta.2-adrenergic receptor by .beta.-adrenergic receptor kinase, cAMP-dependent protein kinase, and protein kinase C occurs via distinct molecular mechanisms

Biochemistry, 1992
Exposure of beta 2-adrenergic receptors (beta 2ARs) to agonists causes a rapid desensitization of the receptor-stimulated adenylyl cyclase response. Phosphorylation of the beta 2AR by several distinct kinases plays an important role in this desensitization phenomenon.
Robert J. Lefkowitz, Martin J. Lohse, Marc G. Caron, Julie A. Pitcher, Juan Codina   +4 more
openaire   +3 more sources

β-Adrenergic Receptor Kinase: Primary Structure Delineates a Multigene Family

Science, 1989
The β-adrenergic receptor kinase (β-ARK), which specifically phosphorylates only the agonist-occupied form of the β-adrenergic and closely related receptors, appears to be important in mediating rapid agonist-specific (homologous) desensitization.
Benovic JL, DE BLASI, ANTONIO, Stone WC, Caron MG, Lefkowitz RJ   +4 more
openaire   +4 more sources

Phosphorylation of chick heart muscarinic cholinergic receptors by the .beta.-adrenergic receptor kinase [PDF]

Biochemistry, 1989
Previous studies have demonstrated that muscarinic cholinergic receptors (mAChR) become markedly phosphorylated when intact cardiac cells are stimulated with a muscarinic agonist. This process appears to be related to the process of receptor desensitization. However, the mechanism of agonist-induced phosphorylation of mAChR is not known.
Robert J. Lefkowitz, M. Marlene Hosey, Jeffrey L. Benovic, Madan M. Kwatra, Marc G. Caron   +4 more
openaire   +3 more sources

Role of beta gamma subunits of G proteins in targeting the beta-adrenergic receptor kinase to membrane-bound receptors.

Science, 1992
The rate and extent of the agonist-dependent phosphorylation of beta 2-adrenergic receptors and rhodopsin by beta-adrenergic receptor kinase (beta ARK) are markedly enhanced on addition of G protein beta gamma subunits.
J. Pitcher, James Inglese, J. B. Higgins, J. Arriza, P. Casey, C. Kim, J. Benovic, M. Kwatra, M. Caron, R. Lefkowitz   +9 more
semanticscholar   +1 more source