Results 261 to 270 of about 60,329 (293)
Some of the next articles are maybe not open access.
Light-dependent phosphorylation of rhodopsin by β-adrenergic receptor kinase
Nature, 1986The structural components involved in transduction of extracellular signals as diverse as a photon of light impinging on the retina or a hormone molecule impinging on a cell have been highly conserved. These components include a recognition unit or receptor (for example, the beta-adrenergic receptor (beta AR) for catecholamines or the 'light receptor ...
J L, Benovic +4 more
openaire +2 more sources
Functional consequences of A1 adenosine-receptor phosphorylation by the β-adrenergic receptor kinase
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1993Treatment of smooth-muscle cells with R-phenylisopropyladenosine (R-PIA) leads to a loss of A1 adenosine receptor (A1AR)-mediated inhibition of adenylate cyclase, a decrease in receptor number and an increase in receptor phosphorylation. In this study, the role of the beta-adrenergic receptor kinase (beta ARK) in the phosphorylation and inactivation of
V, Ramkumar +4 more
openaire +2 more sources
Cardiac Function in Mice Overexpressing the β-Adrenergic Receptor Kinase or a βARK Inhibitor
Science, 1995Transgenic mice were created with cardiac-specific overexpression of the β-adrenergic receptor kinase-1 (βARK1) or a βARK inhibitor. Animals overexpressing βARK1 demonstrated attenuation of isoproterenol-stimulated left ventricular contractility in vivo, dampening of myocardial adenylyl cyclase activity, and reduced functional coupling of β-adrenergic ...
W J, Koch +6 more
openaire +2 more sources
Comparative Analysis of β-Adrenergic Receptor Kinase and β-Arrestin mRNA Expression in Human Cells
Journal of Receptor Research, 1993Receptor phosphorylation is a key step in the process of rapid desensitization. beta-Adrenergic receptor kinase is a specific receptor kinase that is known to phosphorylate and induce desensitization of several G-coupled synaptic receptors only when they are occupied by their agonists.
Parruti G +3 more
openaire +3 more sources
β-Adrenergic Receptor Kinase: Primary Structure Delineates a Multigene Family
Science, 1989The β-adrenergic receptor kinase (β-ARK), which specifically phosphorylates only the agonist-occupied form of the β-adrenergic and closely related receptors, appears to be important in mediating rapid agonist-specific (homologous) desensitization.
Benovic JL +4 more
openaire +2 more sources
Involvement of protein kinase in the regulation of beta-adrenergic receptors by antidepressants.
International journal of clinical pharmacology research, 1989The role of serotonin (5-HT) and protein kinases in the regulation of the beta-receptor induced by typical and atypical antidepressants was investigated. Treatment with either mianserin or maprotiline for seven days produced a significant decrease in the beta-receptor density measured 6h after the last dose.
M, Asakura +9 more
openaire +1 more source
Serum creatine kinase release and alpha- and beta-adrenergic receptors.
Archives internationales de pharmacodynamie et de therapie, 1986Changes in the serum creatine kinase (CK) activity and the mechanism of its release after administration of two kinds of beta-blockers to rats were studied in order to determine the mechanism of the increase in serum CK accompanying administration of beta-blockers.
Y, Jingu, Y, Aoki, H, Itoh, T, Saruta
openaire +1 more source