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The β-adrenergic receptor kinase in heart failure
Journal of Molecular and Cellular Cardiology, 2003Heart failure (HF) remains a significant and increasing cause of worldwide morbidity and mortality. HF is less a disease than a common clinical endpoint resulting from diverse, but often co-existing etiologies-including hypertension, coronary artery disease, and viral cardiomyopathy.
Walter J. Koch, Jason A. Petrofski
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Science, 1993
beta-Adrenergic receptor kinase (beta ARK) and beta-arrestin function in the homologous or agonist-activated desensitization of G protein-coupled receptors. The isoforms beta ARK-2 and beta-arrestin-2 are highly enriched in and localized to the dendritic
Ted M. Dawson +7 more
semanticscholar +1 more source
beta-Adrenergic receptor kinase (beta ARK) and beta-arrestin function in the homologous or agonist-activated desensitization of G protein-coupled receptors. The isoforms beta ARK-2 and beta-arrestin-2 are highly enriched in and localized to the dendritic
Ted M. Dawson +7 more
semanticscholar +1 more source
Light-dependent phosphorylation of rhodopsin by β-adrenergic receptor kinase [PDF]
Nature, 1986 The structural components involved in transduction of extracellular signals as diverse as a photon of light impinging on the retina or a hormone molecule impinging on a cell have been highly conserved. These components include a recognition unit or receptor (for example, the beta-adrenergic receptor (beta AR) for catecholamines or the 'light receptor ...
Robert J. Lefkowitz +4 more
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American Journal of Physiology. Heart and Circulatory Physiology, 2006
Adverse remodeling after myocardial infarction (MI) determines the progression of heart failure. Failing hearts are characterized by downregulation of beta-adrenergic receptor (beta-AR) signaling in part because of increased beta-AR kinase 1 activity ...
A. Curcio +7 more
semanticscholar +1 more source
Adverse remodeling after myocardial infarction (MI) determines the progression of heart failure. Failing hearts are characterized by downregulation of beta-adrenergic receptor (beta-AR) signaling in part because of increased beta-AR kinase 1 activity ...
A. Curcio +7 more
semanticscholar +1 more source
Biochemical and Biophysical Research Communications - BBRC, 1996
We cloned an entire encoding sequence of beta-adrenergic receptor kinase 1 (beta ARK1) cDNA from the hearts of Syrian hamsters through reverse transcription and subsequent polymerase chain reaction.
K. Urasawa +6 more
semanticscholar +1 more source
We cloned an entire encoding sequence of beta-adrenergic receptor kinase 1 (beta ARK1) cDNA from the hearts of Syrian hamsters through reverse transcription and subsequent polymerase chain reaction.
K. Urasawa +6 more
semanticscholar +1 more source
Activation of β-Adrenergic Receptor Kinase During Myocardial Ischemia
Circulation Research, 1996During myocardial ischemia, a local release of noradrenaline coincides with an increased density of β-adrenergic receptors. The functional activity of these receptors, however, is mainly determined by their state of phosphorylation. The β-adrenergic receptor kinase (βARK) specifically phosphorylates and thereby inactivates β-adrenergic receptors after ...
Kai Kronsbein +4 more
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American Journal of Physiology, 1997
To determine the direct functional significance of the beta-adrenergic receptor (AR) kinase 1 (beta ARK1) on myocardial performance in the absence of tonic sympathoadrenal neural activation and mechanical loading, we measured the contractile responses to
D. Korzick +5 more
semanticscholar +1 more source
To determine the direct functional significance of the beta-adrenergic receptor (AR) kinase 1 (beta ARK1) on myocardial performance in the absence of tonic sympathoadrenal neural activation and mechanical loading, we measured the contractile responses to
D. Korzick +5 more
semanticscholar +1 more source
Protein kinase activity of phosphoinositide 3-kinase regulates β-adrenergic receptor endocytosis
Nature Cell Biology, 2005Phosphoinositide 3-kinase (PI(3)K) is a unique enzyme characterized by both lipid and protein kinase activities. Here, we demonstrate a requirement for the protein kinase activity of PI(3)K in agonist-dependent beta-adrenergic receptor (betaAR) internalization.
Aasakiran Madamanchi +3 more
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Molecular Pharmacology, 1997
Two of the common mechanisms regulating G protein-coupled receptor (GPCR) signal transduction are phosphorylation and sequestration (internalization). Agonist-mediated receptor phosphorylation by the beta-adrenergic receptor kinase (betaARK) facilitates subsequent interaction with an arrestin protein, resulting in receptor desensitization.
Larry S. Barak +6 more
openaire +3 more sources
Two of the common mechanisms regulating G protein-coupled receptor (GPCR) signal transduction are phosphorylation and sequestration (internalization). Agonist-mediated receptor phosphorylation by the beta-adrenergic receptor kinase (betaARK) facilitates subsequent interaction with an arrestin protein, resulting in receptor desensitization.
Larry S. Barak +6 more
openaire +3 more sources