Results 121 to 130 of about 889,039 (253)

Self-Prescribed Beta-Blocker Use and Health Implications Among Undergraduate Medical Students at Umm Al-Qura University [PDF]

Khalid Abdulrahman Basamih,1 Asayil Yousef Almarjan,1 Faeqah Raja Allah Alharbi,1 Khalid Fawzi Salaemae,1 Sarah Naif Badahdah,1 Zuhaa Shihab Jaha,2 Anmar Jamil Mandourah3 1Faculty of Medicine, Umm Al-Qura University, Makkah, Kingdom of Saudi Arabia ...
Jaha ZS, Badahdah SN, Almarjan AY, Salaemae KF, Mandourah AJ, Alharbi FRA, Basamih KA   +6 more
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Beta-blocker therapy in heart failure with preserved ejection fraction (B-HFpEF): a systematic review and meta-analysis

IntroductionWhile beta-blockers are considered the cornerstone of treatment for heart failure with reduced ejection fraction, the same may not apply to patients with heart failure with preserved ejection fraction (HFpEF).
Vichithranie Madurasinghe (3438182), Ashfaq Patel (16855122), Ammar Chapra (14777698), Chapra, Ammar, Kaddoura, Rasha, Madurasinghe, Vichithranie, Associate Prof. Daoud Al-Badriyeh (17823431), Dr. Rasha Kaddoura (17823428), Patel, Ashfaq, Abushanab, Dina, Dina Abushanab (10696501), Al-Badriyeh, Daoud   +11 more
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SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Death certificate: Baby Blocker

, 1912
This is a photograph of the death certificate for Baby Blocker, deceased on 1912-07-19, filed with the Arkansas Department of Health by the Ruebel Funeral Home in Little Rock.Transcribed. Gender: female, Race: colored, Date of birth: 1912-07-19, Place of
Ruebel Funeral Home (Little Rock, Ark.)
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Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Beta-blocker under-use in COPD patients

, 2017
Kuan Pin Lim,1,2 Sarah Loughrey,1 Michael Musk,1,2 Melanie Lavender,1,2 Jeremy P Wrobel1–3 1Advanced Lung Disease Unit, Royal Perth Hospital, Perth, WA, Australia; 2Respiratory Department, Fiona Stanley Hospital, Murdoch, WA, Australia; 3School of
Loughrey S, Lavender M, Musk M, Wrobel JP, Lim KP   +4 more
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Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Cardiotoxic Overdoses: Tricyclic Antidepressant, Beta-Blocker, and Calcium-Channel Blocker

Cardiotoxic Overdoses: Tricyclic Antidepressant, Beta-Blocker, and Calcium-Channel Blocker reviews high-risk cardiotoxic overdoses, expected electrocardiographic and hemodynamic findings, supportive care, selected antidotal therapies, repeated monitoring,
Casey C. Sears
core   +1 more source