Results 151 to 160 of about 104,267 (299)

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

Beta-blocker therapy after myocardial infarction: an umbrella review. [PDF]

EClinicalMedicine
Cataldo-Miranda P, Cao PK, Koh HJW, Gasevic D, Chodapuneedi S, Eliakundu AL, Romero L, Stub D, Zoungas S, Kaye DM, Talic S.   +10 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Prevalence of Beta Blocker Prescribing for Hypertension. [PDF]

J Pharm Technol
Skory BJ, Arko J, Terkawi L, Slusarz E, King O, Deokarran C, Glista K, Will M, Etemadi H, Brosch E, Wasowski E, Soric MM.   +11 more
europepmc   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Beta Blocker Toxicity at Therapeutic Doses: A Look Into Carvedilol Use in the Elderly. [PDF]

Clin Case Rep
Amo-Tachie S.
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Use of beta-blocker therapy in older patients after acute myocardial infarction in Ontario.

, 2009
BACKGROUND: Despite its proven efficacy, beta-blocker therapy remains underused in elderly patients after myocardial infarction (MI). The objectives of this study were to identify undertreated groups of seniors and to determine whether older and frailer ...
Lau, Paula, Clark, Jocalyn P., Szalai, John Paul, Gurwitz, Jerry H., Rochon, Paula A., Anderson, Geoffrey M., Tu, Jack V.   +6 more
core  

Beta-Blocker Interruption or Continuation after Myocardial Infarction

International audienceBackground: The appropriate duration of treatment with beta-blocker drugs after a myocardial infarction is unknown. Data are needed on the safety and efficacy of the interruption of long-term beta-blocker treatment to reduce side ...
Deharo, Pierre, Lim, Pascal, Besseyre Des Horts, Timothée, Diallo, Abdourahmane, El Kasty, Mohamad, Slama, Michel, Jourda, François, Petroni, Thibault, Fourme, Thierry, Aacha, Karim, Ivanes, Fabrice, Montalescot, Gilles, Redjimi, Nassim, Boccara, Franck, Thuaire, Christophe, Lattuca, Benoit, Dumaine, Raphaelle, Lemesle, Gilles, Procopi, Niki, Leclercq, Florence, Delarche, Nicolas, Furber, Alain, Bresoles, François, Vicaut, Eric, Lhermusier, Thibault, Ferrari, Emile, Cuisset, Thomas, Payot, Laurent, Labeque, Jean-Noël, Range, Grégoire, Cayla, Guillaume, Pommier, Thibaut, Puymirat, Etienne, Silvain, Johanne, Guedeney, Paul, Dillinger, Jean-Guillaume   +35 more
core   +1 more source

Beta Blocker Intoxications in Belgium: A Data Analysis with Focus on Propranolol. [PDF]

Pharmacy (Basel)
van den Boogaard B, van de Lavoir M, Robeyns R, Gys C, Covaci A, De Loof H.   +5 more
europepmc   +1 more source