Results 191 to 200 of about 13,428,920 (391)

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source

Etoposide‐induced cancer cell death: roles of mitochondrial VDAC1 and calpain, and resistance mechanisms

Molecular Oncology, EarlyView.
The complex mode of action of the topoisomerase II inhibitor etoposide in triggering apoptosis involves several mechanisms: overexpression of the mitochondrial protein VDAC1, leading to its oligomerization and formation of a large channel that mediates the release of pro‐apoptotic protein; and overexpression of the apoptosis regulators p53, Bax, and ...
Aditya Karunanithi Nivedita, Varda Shoshan‐Barmatz   +1 more
wiley   +1 more source

Ray calculations of ocean sound channels using a pocket programmable calculator and extended forms of the Hirsch-Carter mathematical model with tables of the incomplete beta function [PDF]

, 1978
Lincoln Baxter
openalex   +1 more source

Beta-Cell Function and Failure [PDF]

, 2013
s of the 62nd Scientific Sessions of the American Diabetes Association, 14(18), 2002, San Francisco, California. Diabetes, Volume 51, Supplement 2. [22] Soltani N, Keshavarz M, Dehpour AR. 2007. Effect of oral magnesium sulfate admin‐ istration on blood pressure and lipid profile in streptozocin diabetic rat.Eur J Phar‐ macol.
openaire   +3 more sources

Respiratory complex I‐mediated NAD+ regeneration regulates cancer cell proliferation through the transcriptional and translational control of p21Cip1 expression by SIRT3 and SIRT7

Molecular Oncology, EarlyView.
NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi, Kazunori Mori, Hidetsugu Nakagawa, Momoko Uchida, Fumihiro Ishikawa, Motoko Shibanuma   +5 more
wiley   +1 more source

On Extended Beta Function and Related Inequalities

Mathematics
In this article, we consider a unified generalized version of extended Euler’s Beta function’s integral form a involving Macdonald function in the kernel. Moreover, we establish functional upper and lower bounds for this extended Beta function.
Rakesh K. Parmar, Tibor K. Pogány, Ljiljana Teofanov   +2 more
doaj   +1 more source

Integral inequalities under beta function and preinvex type functions. [PDF]

Springerplus, 2016
Ahmad I.
europepmc   +1 more source

Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer

Molecular Oncology, EarlyView.
We used whole exome and RNA‐sequencing to profile divergent genomic and transcriptomic landscapes of microsatellite stable (MSS) and microsatellite instable (MSI) colorectal cancer. Alterations were classified using a computational score for integrative cancer variant annotation and prioritization.
Efstathios‐Iason Vlachavas, Konstantinos Voutetakis, Vivian Kosmidou, Spyridon Tsikalakis, Spyridon Roditis, Konstantinos Pateas, Ryangguk Kim, Kymberleigh Pagel, Stephan Wolf, Gregor Warsow, Antonia Dimitrakopoulou‐Strauss, Georgios N. Zografos, Alexander Pintzas, Johannes Betge, Olga Papadodima, Stefan Wiemann   +15 more
wiley   +1 more source

Integral Transforms for the New Generalized Beta Function

Journal of New Theory, 2019
In this paper, some representation formulas for the generalized Gamma and Beta functions are obtained. Also, certain integral transforms for the generalized Beta function associated with the Wright hypergeometric function are derived.
Ahmed Ali Al-gonah, Waleed Khadher Mohammed   +1 more
doaj  

Structure-function analysis of the Abm12 beta mutation using site-directed mutagenesis and DNA-mediated gene transfer. [PDF]

, 1987
Franca Ronchese, Matthew A. Brown, R N Germain   +2 more
openalex   +1 more source