Results 231 to 240 of about 1,095,525 (267)

Decoding adult murine pancreatic islet cell diversity through cell type-resolved proteomics and phosphoproteomics. [PDF]

Commun Biol
Thielert M, Villalba A, Brennsteiner V, Wahle M, Ammar C, Brunner AD, Fouque A, Lourenço C, Oshima M, Rachdi L, Staels W, Mann M, Scharfmann R.   +12 more
europepmc   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Trends in Conventional Heart Failure Therapy in a Real-World Multinational ATTR-CA Cohort. [PDF]

J Cardiovasc Dev Dis
van der Geest EH, Ajmone Marsan N, Laenens D, Debonnaire PJMR, Claeys M, Pinto F, Brito D, Donal E, Droogmans S, Van de Veire N, Bertrand P, Nabeta T, Graziani F, Regeer MV.   +13 more
europepmc   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Dynamical study of different types of soliton solutions with bifurcation, chaos and sensitivity analysis to the non-linear coupled Schrödinger model. [PDF]

Sci Rep
Nasir R, Abbas M, Alharthi MR, Nazir T, Yousaf MZ, Birhanu A.   +5 more
europepmc   +1 more source

The photoswitchable cannabinoid azo‐HU308 enables optical control of Ca2+ dynamics in INS‐1 β‐cells via off‐target effects on TRPC channels

FEBS Open Bio, EarlyView.
Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley   +1 more source

Cardioprotective Mechanisms of Beta-Blockers in Myocardial Ischemia and Reperfusion: From Molecular Targets to Clinical Implications. [PDF]

Int J Mol Sci
Nasoufidou A, Bantidos MG, Fyntanidou B, Kofos C, Stachteas P, Arvanitaki A, Karakasis P, Sagris M, Kassimis G, Fragakis N, Karagiannidis E.   +10 more
europepmc   +1 more source

Evaluating the role of alpha cell dysregulation in the progression to type 2 diabetes using mathematical simulations. [PDF]

Diabetologia
Subramanian V, Sherman AS, Holst JJ, Knop FK, Vilsbøll T, Bagger JI.   +5 more
europepmc   +1 more source

Roles of beta synchronisation for motor skill acquisition change after stroke

Timmsen LS, Haverland B, Wolf S, Stagg CJ, Feldheim J, Luu TV, Schulz R, Schneider TR, Quandt F, Schwab BC.   +9 more
europepmc   +1 more source

Effect of short-term (4 weeks) low-calorie diet induced weight loss on beta-cell function in overweight normoglycemic subjects: A quasi-experimental pre-post interventional study. [PDF]

Metabol Open
Peter M, Balaji M, Varghese J, Marconi S, Sudhakar Y, Jebasingh F, Venkatesan P.   +6 more
europepmc   +1 more source