Survival, bacterial clearance and thrombocytopenia are improved in polymicrobial sepsis by targeting nuclear transport shuttles. [PDF]
PLoS ONE, 2017 The rising tide of sepsis, a leading cause of death in the US and globally, is not adequately controlled by current antimicrobial therapies and supportive measures, thereby requiring new adjunctive treatments.
Ruth Ann Veach +6 more
doaj +2 more sources
C9orf72 arginine-rich dipeptide repeat proteins disrupt karyopherin-mediated nuclear import
eLife, 2020 Disruption of nucleocytoplasmic transport is increasingly implicated in the pathogenesis of neurodegenerative diseases, including ALS caused by a C9orf72 hexanucleotide repeat expansion. However, the mechanism(s) remain unclear.
Lindsey R Hayes +4 more
doaj +1 more source
Nuclear Import and Export Signals of Human Cohesins SA1/STAG1 and SA2/STAG2 Expressed in Saccharomyces cerevisiae [PDF]
, 2012 Background: Human SA/STAG proteins, homologues of the yeast Irr1/Scc3 cohesin, are the least studied constituents of the sister chromatid cohesion complex crucial for proper chromosome segregation.
Jurek, Marta +27 more
core +1 more source
Nuclear transport factors: global regulation of mitosis [PDF]
, 2015 The unexpected repurposing of nuclear transport proteins from their function in interphase to an equally vital and very different set of functions in mitosis was very surprising.
Bernis, Cyril +3 more
core +1 more source
Spatial regulation of the Start repressor Whi5 [PDF]
, 2009 The Saccharomyces cerevisiae Start repressor Whi5, the functional analogue of mammalian pRB, shuttles between the nucleus and the cytoplasm throughout the cell cycle: enters into the nucleus at the end of mitosis and remains nuclear until Start.
Quilis, Inmaculada +2 more
core +1 more source
Kap-Centric control of nuclear pores based on promiscuous binding to FG nucleoporins [PDF]
, 2014 Nuclear pore complexes (NPCs) are remarkable molecular machines that perforate the nuclear envelope (NE) in eukaryotic cells and mediate the rapid bidirectional traffic of hundreds of proteins, ribonucleoproteins, and metabolites across the nuclear ...
Wagner, Raphael S.
core +1 more source
Reduction of dimensionality in Karyopherinβ1 mediated transport on FG domains [PDF]
, 2014 Many molecular transport processes in living cells proceed by facilitated diffusion in two dimensions instead of three, but how this process works remains poorly understood.
Schleicher, Kai D.
core +1 more source
Nuclear import of yeast Gcn4p requires karyopherins Srp1p and Kap95p
, 2004 The yeast transcription factor Gcn4p contains two stretches of amino acid residues, NLS1 and NLS2, which are independently able to relocate the cytoplasmic protein chorismate mutase into the nucleus. Only NLS2 is conserved among fungi.
Draht, Oliver W. +4 more
core +1 more source
The histone chaperones Nap1 and Vps75 bind histones H3 and H4 in a tetrameric conformation [PDF]
, 2011 Histone chaperones physically interact with histones to direct proper assembly and disassembly of nucleosomes regulating diverse nuclear processes such as DNA replication, promoter remodeling, transcription elongation, DNA damage, and histone variant ...
Bowman, Andrew +16 more
core +1 more source
NOTES Ebolavirus VP24 Binding to Karyopherins Is Required for Inhibition of Interferon Signaling
, 2009 The Ebolavirus VP24 protein counteracts alpha/beta interferon (IFN-/) and IFN- signaling by blocking the nuclear accumulation of tyrosine-phosphorylated STAT1 (PY-STAT1). According to the proposed model, VP24 binding to members of the NPI-1 subfamily of
Basler, Christopher +9 more
core +1 more source