Results 131 to 140 of about 15,641,513 (303)
Beta Risk and Regime Shift in Market Volatility [PDF]
In this paper, we relate security returns in the thirty securities in the Dow Jones index to regime shifts in the market portfolio (S&P500) volatility. We model market volatility as a multiple-state Markov switching process of order one and estimate non ...
Don U.A. Galagedera, Roland G. Shami
core
Basic and Clinical Neuroscience, 2016 Introduction: Alzheimer’s disease (AD) is one of the most common neurodegenerative disorders, which has much benefited from animal models to find the basics of its pathophysiology.
Mohammad Javad Eslamizade +8 more
doaj
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Frontiers in EndocrinologyThe pancreas is smaller in individuals with type 1 and type 2 diabetes. The etiology of this reduced pancreatic volume is not fully understood, but it may be due to loss of insulin’s trophic influence on exocrine pancreatic tissue.
John Virostko, John Virostko
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Is systematic downside beta risk really priced? Evidence in emerging market data [PDF]
Several studies advocating safety first as a major concern to investors propose downside beta risk as an alternative to the traditional systematic risk-beta.
Robert D. Brooks, Don U.A. Galagedera
core
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
La difesa di Diceopoli e le arti retoriche di Euripide negli Acarnesi di Aristofane
, 1999 Attraverso l'analisi di una scena degli Acarnesi di Aristofane (vv. 393-489), Simone Beta mostra come le bizzarre richieste dell'eroe comico Diceopoli siano il modo con il quale Aristofane ha cercato di prendere in giro alcune caratteristiche retoriche ...
BETA, SIMONE
core +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source