Results 201 to 210 of about 1,115,045 (263)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Acylcarnitines and prediction of renal function decline in type 2 diabetes. [PDF]

BMJ Open Diabetes Res Care
Trischitta V, Fontana A, Shah H, Mastroianno M, Prehn C, De Cosmo S, Adamski J, Copetti M, Doria A, Menzaghi C.   +9 more
europepmc   +1 more source

Tilted beta regression and beta-binomial regression models: Mean and variance modeling

Communications for Statistical Applications and Methods
openaire   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

A Single Session of Slackline Training Induces Rapid, Task-Specific Balance Improvements and Elevated Resting-State Beta Band Power. [PDF]

Eur J Sport Sci
Kenville R, Groß D, Helbich M, Behrens H, Ragert P, Maudrich T.   +5 more
europepmc   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Gut Microbiome Variation Across Menstrual Phases: Distinct Roles of Diet and Physiological Hormonal Fluctuations in Healthy Women

Sanna S, Faro VL, Forabosco P, Crobu F, Carta A, Busonero F, Maschio A, Viscito M, Lenarduzzi S, Vriz GB, Badalini A, Ferrando M, Chillotti F, Incollu S, Murrau D, De Seta F, Ricci G, Barbara G, Guerriero S, Meloni A, Barbaro M, Girotto G, Zhernakova D, Camarda S.   +23 more
europepmc   +1 more source

Garbage in, garbage out: stringent quality control of behavioral data boosts signal in brain-behavior associations. [PDF]

Cereb Cortex
Elsayed M, Deng WQ, Belisario KL, MacKillop J.   +3 more
europepmc   +1 more source

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

Hepatic Fat Quantification Using Beta Distribution and a Probabilistic Neural Network in a Prepubertal Male Cohort. [PDF]

Diagnostics (Basel)
Ramírez-Bautista MA, de Celis Alonso B, Rojas GUP, Cocoletzi-Adame F, Tobón SSH, Arredondo-Velázquez M, Moreno-Barbosa E, Hernández-López JM, So PW, Velázquez-Castro J.   +9 more
europepmc   +1 more source