Results 61 to 70 of about 64,895 (239)
An Extension of Generalized Linear Models to Finite Mixture Outcome Distributions
, 2016 Finite mixture distributions arise in sampling a heterogeneous population. Data drawn from such a population will exhibit extra variability relative to any single subpopulation.
Morel, Jorge G. +2 more
core +1 more source
Identifying Tipping Points during Healthy Brain Aging through Single‐Nucleus Transcriptomic Analysis
Advanced Science, EarlyView.This study applies single‐nucleus transcriptomics and systems dynamics to uncover nonlinear aging patterns in healthy human brains. By introducing dynamic network biomarker theory, the authors identify a critical tipping point at ages 56–60 during aging, and highlight glial instability as a key mediator.
Peiru Wu +9 more
wiley +1 more source
Revista Colombiana de Estadística, 2009 When analyzing data in the presence of over dispersion, the usual practice is to assume a common dispersion parameter to all observations. However, there are situations where the assumption of homogeneity of the dispersion parameter does not hold.
Morales Mario Alfonso +1 more
doaj
A local limit theorem assuming finite second moments via Stein’s method
Arab Journal of Basic and Applied SciencesLet [Formula: see text] be independent but not necessarily identically distributed integer-valued random variables and let [Formula: see text] Estimation of the point probabilities [Formula: see text] is a common problem that occurs in many applied ...
Graeme Auld, Kritsana Neammanee
doaj +1 more source
Beta-Negative Binomial Process and Exchangeable Random Partitions for Mixed-Membership Modeling [PDF]
, 2014 The beta-negative binomial process (BNBP), an integer-valued stochastic process, is employed to partition a count vector into a latent random count matrix.
Zhou, Mingyuan
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Advanced Science, EarlyView.The 2500‐year‐old Mulberry‐dyke and Fish‐pond agricultural heritage system reveals how interconnected habitats foster microbial diversity. Multi‐habitat landscapes enhance microbial diversity through cross‐habitat dispersal and adaptive trait convergence. Globally, regions with diverse habitats support a greater diversity of soil microbiomes.
Jintao He +8 more
wiley +1 more source
ACSS2/AATF Drives Soluble FasL‐Mediated CD8+ T Cell Apoptosis in Pancreatic Neuroendocrine Tumors
Advanced Science, EarlyView.This study unveils that ACSS2‐driven acetate metabolism fuels histone pan‐acetylation in pancreatic neuroendocrine tumors (PNETs), remodeling the epigenetic landscape. The ACSS2/AATF axis transcriptionally activates soluble FasL (sFasL), which engages Fas receptors on infiltrating CD8+ T cells to trigger caspase‐8/3‐mediated apoptosis.
Qin Dang +14 more
wiley +1 more source
The Dirichet-Multinomial model for multivariate randomized response data and small samples [PDF]
, 2012 In survey sampling the randomized response (RR) technique can be used to obtain truthful answers to sensitive questions. Although the individual answers are masked due to the RR technique, individual (sensitive) response rates can be estimated when ...
Avetisyan, M., Fox, G.J.A.
core +1 more source
Advanced Science, EarlyView.An integrative analysis combining in vitro genome‐wide immune screens, in vivo ICB screens, and clinical data mining identifies METTL5 as a key tumor‐intrinsic immune factor. Mechanistic studies further reveal the importance of the METTL5‐ATF4‐SLC7A11/SLC3A2‐ferroptosis axis in modulating antitumor immune responses. These findings highlight METTL5 as a
Jiakai Hou +30 more
wiley +1 more source
Advanced Science, EarlyView.A high resolution integrated cell atlas of the pig intestine provides insights into the genetic mechanisms of complex traits (Created in BioRender. Yu, P. (2025) https://BioRender.com/o14c563) Abstract The porcine intestinal tract is vital for nutrient absorption, immune regulation, and various physiological processes.
Pengfei Yu +14 more
wiley +1 more source