Results 91 to 100 of about 404,647 (233)

NDST3‐Induced Epigenetic Reprogramming Reverses Neurodegeneration in Parkinson's Disease

Advanced Science, EarlyView.
NDST3‐mediated epigenetic reprogramming revitalizes neuronal circuits in the substantia nigra and striatum to halt dopaminergic neuron degeneration and restore motor function in Parkinson's disease models. This strategy promotes neuronal maintenance and functional recovery, highlighting NDST3's therapeutic potential in neurodegenerative disorders ...
Yujung Chang, Yongwoo Na, Hyeonjoo Im, Garam Yang, Seungseon Yang, Hyun Soo Shim, Chunggoo Kim, GyeungYun Kim, Hyeok Ju Park, Hee Young Kim, Seung Eun Lee, Wonwoong Lee, Yoon Ha, Sungho Park, Jieun Kim, Won‐Young Cho, Woong Sun, Jong‐Seo Kim, Junsang Yoo   +18 more
wiley   +1 more source

High‐Asymmetry Metasurface: A New Solution for Terahertz Resonance via Active Learning‐Augmented Diffusion Model

Advanced Science, EarlyView.
A prior knowledge‐guided diffusion model augmented by physics‐constrained active learning is developed to design high‐asymmetry terahertz metamaterials. Trained on only a small set of classical structures, the model efficiently generates new high‐metrics designs.
Qiqi Dai, Yinpeng Wang, Cheng Xu, Dongxiao Li, Prakash Pitchappa, Thomas Caiwei Tan, Ranjan Singh, Chengkuo Lee   +7 more
wiley   +1 more source

Advanced Stem Cell Therapy: 3D‐Bioprinted Brain‐Like Transplants for Alzheimer's Disease‐Like Dementia

Advanced Science, EarlyView.
A tri‐component biomimetic bioink(gelatin/alginate/fibrinogen) is developed to protect cells in critical pathological environments in AD. Using this bioink, a 3D‐printed NPC construct optimized for hippocampal transplantation is provided to improve cell retention and differentiation in an AD‐like model. This approach enhances memory recovery and offers
Ke Gai, Yu Song, Dawen Gao, Qingning Nie, Xiao Luo, Caizhe Xu, Changhao Cai, Austin Smith, Xiang Li, Wei Shi, Lei Zhang, Wei Sun, Feng Lin   +12 more
wiley   +1 more source

Environmental and Ecological Monitoring with Biodegradable Technologies

Advanced Science, EarlyView.
This review examines the development and application of wireless biodegradable sensors for environmental monitoring. It explores (bio)degradable materials, their degradation mechanisms in various environments, and non‐toxic fabrication techniques. Additionally, it addresses scalable production and sustainable powering solutions, emphasizing the high ...
Mohammad Javad Bathaei, Yaren Bathaei, Zhengwei Liao, Maryam Yazdanmehr, Sarab S. Sethi, Denys Nikolayev, Filipe Arroyo Cardoso, Clementine M. Boutry   +7 more
wiley   +1 more source

Shannon Entropy of Gray Matter Eigenmodes: A Novel Biomarker for Alzheimer's Disease and Heterogeneous MCI Trajectories

Advanced Science, EarlyView.
Entropy derived from gray matter eigenmodes captures cortical disorganization in Alzheimer's disease. Using multimodal MRI and amyloid‐PET data, this novel structure–function coupling biomarker enables accurate classification of clinical stages, predicts Aβ burden, and stratifies mild cognitive impairment subtypes.
Yumeng Li, Gaoping Long, Xinyue Zhang, Kewei Chen, Xin Li, Zhanjun Zhang   +5 more
wiley   +1 more source

Accurate Generation of Conformational Ensembles for Intrinsically Disordered Proteins with IDPFold

Advanced Science, EarlyView.
In brief: IDPFold predicts the conformational ensembles of intrinsically disordered proteins (IDPs) from their amino acid sequences. The atomic structures generated by IDPFold offer crucial insights into the intricate relationship between IDP structures and their diverse biological functions.2 Abstract Intrinsically disordered proteins (IDPs) play ...
Junjie Zhu, Zhengxin Li, Zhuoqi Zheng, Bo Zhang, Bozitao Zhong, Jie Bai, Xiaokun Hong, Taifeng Wang, Ting Wei, Jianyi Yang, Hai‐Feng Chen   +10 more
wiley   +1 more source

Genetically Engineered Light‐Responsive In Situ Hydrogels for Immunomodulation and Multimodal Therapy in Metastatic Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Cysteine‐tagged silk‐elastin‐like proteins, a family of tri‐block chimeric proteins that consist of a photothermal agent binding motif, silk motif, and elastin motif is developed to form a responsive in situ hydrogel for late‐stage and metastatic triple‐negative breast cancer.
Xinchen Shen, Jiajia Zhang, Junhan Ou, Ziheng Bai, Tongyan Liu, Kaiyue Zhang, Kaixiang Zhu, James Q. Wang, Chaochen Wang, Qianting Zhang, Linrong Lu, Wenwen Huang   +11 more
wiley   +1 more source

EasyAmplicon 2: Expanding PacBio and Nanopore Long Amplicon Sequencing Analysis Pipeline for Microbiome

Advanced Science, EarlyView.
EasyAmplicon 2 is an updated, user‐friendly, and community‐supported pipeline designed for full‐length amplicon data from long‐read sequencing technologies such as PacBio and Nanopore. It supports multiple platforms (Illumina, PacBio, Nanopore, etc.), integrates tools like DADA2 and Emu, and offers a complete workflow from raw data processing to high ...
Hao Luo, Defeng Bai, Zhihao Zhu, Salsabeel Yousuf, Haifei Yang, Jiani Xun, Meiyin Zeng, Yao Wang, Yunyun Gao, Kai Peng, Shanshan Xu, Yuanping Zhou, Tianyuan Zhang, Chuang Ma, Huiyu Hou, Xiulin Wan, Yang Zhou, Baolei Jia, Shi Huang, Renyou Gan, Tao Wen, Tong Chen, Xia Chen, Xiaofang Li, Yong‐Xin Liu   +24 more
wiley   +1 more source

Probabilistic MIC modelling for AMR risk assessment. [PDF]

EFSA J
Baños AP, Stefanou CR, Stathas L, Papagianeli SD, Ordóñez AÁ, Doulgeraki A, Koutsoumanis K.   +6 more
europepmc   +1 more source

Erucic Acid, Derived by Lactobacillus Crispatus, Induces Ferroptosis in Cervical Cancer Organoids Through the PPAR‐δ Signaling Pathway

Advanced Science, EarlyView.
Utilizing PDO, cell lines and cervical cancer xenograft (CDX) models, the study demonstrate both in vitro and in vivo that the metabolite of L. crispatus, erucic acid, can modulate the proliferation, migration and invasion of cervical cancer by activating the PPAR‐δ pathway.
Qianwei Zhen, Yuexuan Xu, Ying Xu, Xiao Liu, Yuting Zhang, Dan Ye, Sai Han, Shili Liu, Youzhong Zhang   +8 more
wiley   +1 more source