Results 101 to 110 of about 13,941 (202)

Boron Nitride Nanomaterials Trigger Immunomodulatory Effects in Human Broncho‐Epithelial Cells by Modulating Eicosanoid Lipid Signaling

Advanced Science, EarlyView.
This study demonstrates that BNNT exposure disrupts lipid homeostasis in bronchial epithelial cell cultures and activates eicosanoid lipid biosynthesis, producing inflammatory lipid mediators like leukotrienes. These effects are more pronounced in asthmatic cell cultures compared to healthy ones.
Govind Gupta, Jonas Bossart, Sènan Mickael D'Almeida, Luis Augusto Visani de Luna, Christoph Schwärzler, Tingting Fu, Vanesa Ayala‐Nunez, Alexander Gogos, Marija Buljan, Vera M Kissling, Emmanuel Flahaut, Miguel Garcia, Cyrill Bussy, Peter Wick, Tina Buerki‐Thurnherr   +14 more
wiley   +1 more source

A retrospectively registered pilot randomized controlled trial of postbiotic administration during antibiotic treatment increases microbiome diversity and enriches health-associated taxa. [PDF]

Infect Immun
Schluter J, Jogia W, Matheis F, Ebina W, Sullivan AP, Gordon K, Cruz EFdl, Victory-Hays ME, Heinly MJ, Diefenbach CS, Kang UJ, Peled JU, Foster KR, Levitt A, McLaughlin E.   +14 more
europepmc   +1 more source

Mathematical Prediction for Geometry‐Mediated Cell 3D In‐Growth on Bone Tissue Engineering Scaffolds

Advanced Science, EarlyView.
This study identifies a fundamental pore size dependent pattern of three dimensional bone marrow derived mesenchymal stem cell (BMSC) infiltration within porous scaffolds, where small pores promote horizontal cellular bridging and large pores facilitate vertical migration.
Xiang Gao, Zhijun Yu, Yu Yan, Jiamin Ding, Wangsiyuan Teng, Chenhe Zhou, Minjun Yao, Wenkan Zhang, Shenzhi Zhao, Fangqian Wang, Zhenxuan Shao, Jinfeng Zhou, Xiaoyong Wu, Chengcheng Yu, Liang Chen, Xiaoqiang Jin   +15 more
wiley   +1 more source

The COVID generation: the neurodevelopmental consequences of in-utero COVID-19 exposure. [PDF]

Brain Behav Immun
Weiner S, Wu Y, Cheng JJ, Liggett M, McCants C, Adegbulugbe E, Mears A, Henderson D, Andescavage N, Limperopoulos C.   +9 more
europepmc   +1 more source

Mechanism‐Driven Screening of Membrane‐Targeting and Pore‐Forming Antimicrobial Peptides

Advanced Science, EarlyView.
To combat antibiotic resistance, this study employs mechanism‐driven screening with machine learning to identify pore‐forming antimicrobial peptides from amphibian and human metaproteomes. Seven peptides are validated, showing minimal toxicity and membrane disruption.
Jiaxuan Li, Chenguang Yang, Ruihan Dong, Juan Francisco Bada Juarez, Lei Wang, Maximilian Emanuel Wettstein, Dali Wang, Chan Cao, Ying Lu, Chen Song   +9 more
wiley   +1 more source

Evaluating Retrieval-Augmented Generation-Large Language Models for Infective Endocarditis Prophylaxis: Clinical Accuracy and Efficiency. [PDF]

Int Dent J
Rewthamrongsris P, Thongchotchat V, Burapacheep J, Trachoo V, Khurshid Z, Porntaveetus T.   +5 more
europepmc   +1 more source

Targeting IL27RA Enhances Immunotherapy in Triple‐Negative Breast Cancer by Modulating Tumor Cells and the Tumor Microenvironment

Advanced Science, EarlyView.
IL27RA upregulation drives immune evasion in TNBC by suppressing MHC‐I expression and reprogramming T/NK‐cell states, establishing an immune‐excluded tumor phenotype. Targeting this epithelial‐intrinsic IL27RA–PI3K/AKT axis offers a promising strategy to overcome immunotherapy resistance.
Jiachi Xu, Qian Long, Meirong Zhou, Qitong Chen, Jing Peng, Qingchun Liang, Danhua Zhang, Hui Zhou, Wenjun Yi   +8 more
wiley   +1 more source

GraphPPL.jl: A Probabilistic Programming Language for Graphical Models. [PDF]

Entropy (Basel)
Nuijten WWL, Bagaev D, de Vries B.
europepmc   +1 more source

Spectral Decomposition of Chemical Semantics for Activity Cliffs‐Aware Molecular Property Prediction

Advanced Science, EarlyView.
PrismNet mimics chemical intuition by functioning as a computational prism, refracting molecular graphs into complementary semantic views and spectral frequencies. This dual‐decomposition strategy effectively captures both global topologies and subtle “activity cliff” perturbations.
Chaoyang Xie, Junhu Xu, Guangyi Huang, Shihang Wang, Mutian He, Xinyu Dong, Huiyang Hong, Xiaojun Yao, Qi Wang, Yuquan Li   +9 more
wiley   +1 more source

Development and Value of a Centralized Text Message-based Tracking and Support Program for the PRECIDENTD Study. [PDF]

Med Care
Nelson LA, Bergner EM, Adler A, Yoon C, Mieras K, Simeone E, Lema-Driscoll JI, Everett BM, Wexler DJ, Mayberry LS.   +9 more
europepmc   +1 more source