Results 151 to 160 of about 4,044,085 (243)

Learning to Program "Recycles" Preexisting Frontoparietal Population Codes of Logical Algorithms. [PDF]

J Neurosci
Liu 劉耘非 YF, Bedny M.
europepmc   +1 more source

The E3 Ubiquitin Ligase RLIM Safeguards Oligodendrocyte Development and Myelination by Targeting SLC7A11 for Polyubiquitination to Regulate Ferroptotic Resistance

Advanced Science, EarlyView.
RLIM‐mediated SLC7A11 polyubiquitination is required for SPTBN2‐mediated trafficking and membrane localization of SLC7A11, which enables oligodendrocyte precursor cells to be resistant to ferroptosis and safeguards oligodendrocyte lineage progression and thus myelination.
Yuwei Li, Haijun Zhang, Jieya Zhou, Shiyu Yang, Jingmei Cha, Gaofeng Yan, Shuhua Zhao, Bingyu Mao, Pengcheng Ma   +8 more
wiley   +1 more source

Health Data for Linguistic Minority Group Research in Canada: Proof-of-Concept Centralized Health Care Metadata Repository Development and Usability Study. [PDF]

JMIR Infodemiology
Martin-Schreiber V, Peixoto C, Batista R, Belanger C, Tanuseputro P, Hsu AT, Bjerre LM.   +6 more
europepmc   +1 more source

Identification of an Osteochondral Erosion Process in Gout Driven by Fibrinogen‐Integrin Activation and Local MSU Crystallization

Advanced Science, EarlyView.
Cartilage injury promotes local fibrinogen deposition, which accelerates monosodium urate crystallization and activates integrin‐mediated matrix‐degradation. This self‐amplifying cycle drives gout‐related cartilage erosion. Disrupting fibrinogen deposition or restoring the cartilage barrier could interrupt this vicious cycle.
Hanlin Xu, Simin Bi, Zhechen Liu, Xiaofeng Zhou, Hengwei Qin, Nicola Dalbeth, Minbiao Ji, Yinghui Hua   +7 more
wiley   +1 more source

A Multi-Stage Programming Language for Dynamically Reconfigurable Hardware

, 2008
We present Meta-HDL, a two-stage functional language for writing software which dynamically synthesizes and communicates with structurally specialized circuits.
Adam Megacz, Multi-Stage Programming Language   +1 more
core  

Deep Brain Stimulation as a Rehabilitation Amplifier: A Precision-Oriented, Network-Guided Framework for Functional Restoration in Movement Disorders. [PDF]

J Clin Med
Mateo-Sierra O, De la Casa-Fages B, Martín-Ramírez E, Barreiro-Gómez M, Grandas F.   +4 more
europepmc   +1 more source

Cerium Nanoparticle‐Mediated Inhibition of the NSUN2/m5C Axis Suppresses Synovial Aggression in Rheumatoid Arthritis

Advanced Science, EarlyView.
A novel epitranscriptomic mechanism in rheumatoid arthritis is uncovered: NSUN2 promotes disease via m5C‐dependent stabilization of ICMT mRNA, fueling the migration and invasion of pathogenic RA FLS. Targeting this axis with engineered nanoparticles (Ce/SAA NPs) effectively inhibits disease progression, presenting a precise therapeutic strategy ...
Ruiru Li, Simin Chen, Huijuan Hu, Shiyao Wu, Jingnan Wang, Kai Sun, Chenxi Peng, Suling Liu, Shuoyang Zhang, Yu Kuang, Wei Chen, Qian Qiu, Liuqin Liang, Yu Wen, Hanshi Xu, Youjun Xiao   +15 more
wiley   +1 more source

Amygdala and hippocampal contributions to broad autism phenotype: Project Ice Storm. [PDF]

Transl Psychiatry
Li X, Qureshi MNI, Laplante DP, Elgbeili G, Jones SL, King S, Rosa-Neto P.   +6 more
europepmc   +1 more source

CXCL10/SLC11A1 Axis Exacerbates Septic Liver Injury by Regulating Neutrophil Extracellular Traps Formation to Drive Macrophage Pro‑Inflammatory Polarization

Advanced Science, EarlyView.
In sepsis‐induced liver injury, marked neutrophil infiltration correlates with disease severity. Neutrophil SLC11A1 drives intracellular Fe2+ and ROS via the Fenton reaction, promoting NETs formation. Hepatocyte‐derived CXCL10 recruits neutrophils and activates the JAK/STAT1/SLC11A1 axis, enhancing NETs‐mediated inflammation.
Haiping Lin, Shicong Zheng, Pei Song, Jie Chang, Zewei Chen, Cang Li, Min Yu, Lude Wang, Shian Yu   +8 more
wiley   +1 more source

SolanoConnex: developing a web-app for accessing local, up-to-date mental health services in a diverse county. [PDF]

Mhealth
Brody C, Star A, Kelly V, Hoskins T.
europepmc   +1 more source