Results 81 to 90 of about 406,411 (253)
Molecular Oncology, EarlyView.Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant +11 more
wiley +1 more source
Spatial and Predictive Modelling for Antimicrobial Resistance in Livestock: A Systematic Review
UMYU Scientifica JournalAntimicrobial resistance (AMR) in livestock has emerged as a major global threat, with direct implications for public health, food security, and sustainable development under the One Health framework.
Rodiat Olabisi Omotoso +3 more
doaj +1 more source
Double Generalized Beta-Binomial and Negative Binomial Regression Models
Revista Colombiana de Estadística, 2017 Overdispersion is a common phenomenon in count datasets, that can greatly affect inferences about the model. In this paper develop three joint mean and dispersion regression models in order to fit overdispersed data.
EDILBERTO CEPEDA-CUERVO +1 more
doaj +1 more source
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Extended Beta Regression in R: Shaken, Stirred, Mixed, and Partitioned
Journal of Statistical Software, 2012 Beta regression – an increasingly popular approach for modeling rates and proportions – is extended in various directions: (a) bias correction/reduction of the maximum likelihood estimator, (b) beta regression tree models by means of recursive ...
Bettina Grün +2 more
doaj
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Scale-Location-Truncated Beta Regression: Expanding Beta Regression to Accommodate 0 and 1
Beta regression is frequently used when the outcome variable y is bounded within a specific interval, transformed to the (0, 1) domain if necessary. However, standard beta regression cannot handle data observed at the boundary values of 0 or 1, as the likelihood function takes on values of either 0 or infinity.
Kim, Mingang +3 more
openaire +2 more sources
Molecular Oncology, EarlyView.The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant +7 more
wiley +1 more source
A COVINDEX based on a GAM beta regression model with an application to the COVID-19 pandemic in Italy. [PDF]
Stat Methods Appt, 2022 Scrucca L.
europepmc +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source