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Beta-thalassemia Intermedia: An Overview
Pediatric Annals, 2008<P>Thalassemias are inherited anemias characterized by decreased or absent globin chain synthesis and by ineffective erythropoesis. They are classified according to the defective globin chain and to the clinical severity. Beta-thalassemias, which are prevalent in the Mediterranean region, have decreased or absent beta-globin chain synthesis ...
F. El Rassi +3 more
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Human Gene Therapy, 2019
Seventy-five percent of patients with beta thalassemia (β-thalassemia) do not have human leukocyte antigen-matched siblings and until recently had no access to a curative treatment.
S. Coquerelle +15 more
semanticscholar +1 more source
Seventy-five percent of patients with beta thalassemia (β-thalassemia) do not have human leukocyte antigen-matched siblings and until recently had no access to a curative treatment.
S. Coquerelle +15 more
semanticscholar +1 more source
Hypertriglyceridemia in homozygous beta thalassemia
The Journal of Pediatrics, 1975A case of hypertriglyceridemia in association with homozygous beta-thalassemia in an 11-month-old female infant is reported. The hypertriglyceridemia proved to be secondary, as it was indicated by clinical features as well as laboratory findings. Attention is called to a possible alteration of lipid metabolism in association with thalassemia major.
Rex B. Conn +3 more
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C3 Polymorphism in Beta-Thalassemia
Acta Haematologica, 1984The distribution of phenotypes and gene frequencies of the third component of complement (C3) were studied in 106 beta-thalassemic patients and in 112 carriers of the beta-thalassemia trait. A statistically significant association was found between the C3F gene and homozygous beta-thalassemia.
C. Politi +4 more
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Ophthalmic Evaluation in Beta-Thalassemia
The Indian Journal of Pediatrics, 2017To determine the association of ocular manifestations in beta-thalassemia with the patient's age, blood transfusion requirements, average serum ferritin and dose and duration of iron chelation therapy.Sixty multi-transfused beta thalassemia patients of 12 to 18 y of age on chelation therapy were included in this cross-sectional analysis. Structural and
Neepa Thacker +3 more
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Pycnodysostosis with heterozygous beta-thalassemia
Pediatric Radiology, 1977A 6-year follow-up of a Greek girl with pycnodysostosis associated with heterozygous beta-thalassemia is reported. Active rickets in infancy was superimposed on pycnodysostosis. In the family the autosomal recessive disease, pycnodysostosis, appeared in two of three siblings in combination with the autosomal dominant disease, thalassemia minor.
Gabriele Benz, Edla Schmid-Rüter
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Accelerated atherosclerosis in beta-thalassemia
American Journal of Physiology-Heart and Circulatory Physiology, 2023This work definitively shows for the first time that beta-thalassemia leads to accelerated atherosclerosis. We demonstrated that intravascular hemolysis is a prominent feature in beta-thalassemia and the resulting increases in free heme are mechanistically relevant.
Julian Hurtado +8 more
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Platyspondyly in treated beta-thalassemia
European Journal of Radiology, 1994Flattening of the vertebral bodies with a platyspondyly appearance is described in 14 patients selected for evaluation of short stature from 106 patients affected by thalassemia major, who received an intensive transfusion regimen combined with continuous chelation therapy.
Scutellari Pn +2 more
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β-Thalassemia Mutations in Corsica
Hemoglobin, 2000Screening of beta thalassemia mutations in Corsica.
Varesi L +4 more
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Hematology/Oncology Clinics of North America, 2023
This article reviews the classification of beta-thalassemia syndromes, correlating clinical severity and genotype in the earlier classification, and broadening it recently based on clinical severity and transfusion status. The classification is dynamic, and individuals may progress from transfusion-independent to transfusion-dependent.
Morgan, Pines, Sujit, Sheth
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This article reviews the classification of beta-thalassemia syndromes, correlating clinical severity and genotype in the earlier classification, and broadening it recently based on clinical severity and transfusion status. The classification is dynamic, and individuals may progress from transfusion-independent to transfusion-dependent.
Morgan, Pines, Sujit, Sheth
openaire +2 more sources