Results 81 to 90 of about 20,822 (186)

In Patients with Minor Beta-Thalassemia, Cognitive Performance Is Related to Length of Education, But not to Minor Beta-Thalassemia or Hemoglobin Levels

Iranian Journal of Psychiatry, 2018
Objective: Thalassemia is one of the most frequent monogenic disorders, leading to impairment in the maturation and survival of red blood cells. The question examined here is whether, and if so, to what extent, people with beta-thalassemia might also be ...
Mohammad Ahmadpanah, Yasaman Asadi, Mohammad Haghighi, Hamidreza Ghasemibasir, Elham Khanlarzadeh, Serge Brand   +5 more
doaj  

Prevalence of Candida albicans in the oral cavity of Beta Thalassemia Major and Thalassemia Minor Patients [version 2; peer review: 2 approved]

F1000Research
Aims To examine the correlation between iron, ferritin concentrations, and C. albicans infection in individuals with beta-thalassemia major and beta-thalassemia minor compared with healthy subjects.
Maha Adel Mahmood, Saba Sami Abd Al Wahab   +1 more
doaj   +1 more source

A genetic risk score based on BCL11A and HBS1L‐MYB variants predicts clinical severity in Brazilian sickle cell anaemia patients

British Journal of Haematology, EarlyView.
Summary Individuals with sickle cell anaemia (SCA) exhibit significant clinical heterogeneity influenced by several factors, especially fetal haemoglobin (HbF) levels. Variations in adult HbF levels are partly explained by the co‐inheritance of genetic variants that regulate globin expression.
Gabriela S. Arcanjo, Alexsandro P. Silva, Madi V. Diniz, Igor F. Domingos, Diego A. Pereira‐Martins, Amanda B. Araújo, Talita S. S. França, Ana C. Anjos, Aderson S. Araujo, Edis Belini‐Junior, Sara T. O. Saad, Fernando F. Costa, Antonio R. Lucena‐Araujo, Marcos André C. Bezerra   +13 more
wiley   +1 more source

Oxidative stress and antioxidant status in beta-thalassemia heterozygotes

Revista Brasileira de Hematologia e Hemoterapia, 2013
Background: Several studies have evaluated the oxidant and antioxidant status of thalassemia patients but most focused mainly on the severe and intermediate states of the disease.
Luciana de Souza Ondei, Isabeth da Fonseca Estevao, Marina Ibelli Pereira Rocha, Sandro Percario, Doroteia Rossi Silva Souza, Marcela Augusta de Souza Pinhel, Claudia Regina Bonini-Domingos   +6 more
doaj   +1 more source

Longitudinal Analysis of Sleep‐Disordered Breathing and Cognitive Outcomes in Children Living With Sickle Cell Anaemia

Clinical Otolaryngology, EarlyView.
ABSTRACT Objectives Sleep‐disordered breathing (SDB) and cognitive challenges are commonly observed in children living with sickle cell anaemia (SCA). This study investigated the longitudinal change in polysomnographic outcomes and the association with cognitive functions in children living with SCA.
Shifa Hamdule, Melanie Koelbel, Johanna C. Gavlak, Sati Sahota, Fenella J. Kirkham, Anna M. Hood   +5 more
wiley   +1 more source

Molecular analysis of beta-globin gene mutations among Thai beta-thalassemia children: results from a single center study

The Application of Clinical Genetics, 2014
Boonchai Boonyawat,1 Chalinee Monsereenusorn,2 Chanchai Traivaree2 1Division of Genetics, Department of Pediatrics, Phramongkutklao Hospital and College of Medicine, Bangkok, Thailand; 2Division of Hematology/Oncology, Department of Pediatrics ...
Boonyawat B, Monsereenusorn C, Traivaree C   +2 more
doaj  

Fuzzy-Based Fusion Model for β-Thalassemia Carriers Prediction Using Machine Learning Technique

Advances in Fuzzy Systems
The abnormality of haemoglobin in the human body is the fundamental cause of thalassemia disease. Thalassemia is considered a common genetic blood condition that has received extensive investigation in medical research globally.
Muhammad Ibrahim, Sagheer Abbas, Areej Fatima, Taher M. Ghazal, Muhammad Saleem, Meshal Alharbi, Fahad Mazaed Alotaibi, Muhammad Adnan Khan, Muhammad Waqas, Nouh Elmitwally   +9 more
doaj   +1 more source

Patient‐Reported Outcomes With Luspatercept Through 5 Years of Treatment in Patients With Non‐Transfusion‐Dependent β‐Thalassemia Treated in the BEYOND Trial

European Journal of Haematology, EarlyView.
ABSTRACT In the phase 2, double‐blind, randomized controlled BEYOND trial (NCT03342404), luspatercept increased hemoglobin levels in patients with non‐transfusion‐dependent β‐thalassemia (NTDT). This study assessed long‐term effects of luspatercept on patient‐reported outcomes (PROs), using data from BEYOND and patients who continued luspatercept ...
Khaled M. Musallam, Maria Domenica Cappellini, Antonis Kattamis, Matthew Dyer, Ahmed Hnoosh, Laurie Eliason, Christopher G. Pelligra, Shien Guo, Yutian Mu, Loyse Felber Medlin, Marta Reverte, Kevin H. M. Kuo, Ali T. Taher   +12 more
wiley   +1 more source

Identification of a Neonate with Thalassemia Intermedia Despite Premarital Screening Program in Mazandaran Province (Co-inheritance of Hb Knossos and IVS II-1 G> A Mutations)

Research in Molecular Medicine, 2017
Background: Beta thalassemia is a common health problem in Iran especially in Northern provinces. Premarital screening for thalassemia is compulsory in Iran and identification of the carriers is based on primary CBC (Cell Blood Count) and hemoglobin ...
Hossein Karami, Hossein Jalali, Mehrad Mahdavi, Mohammad Reza Mahdavi   +3 more
doaj  

An Aγ-globin G->A gene polymorphism associated with β(0)39 thalassemia globin gene and high fetal hemoglobin production [PDF]

, 2017
Increase of the expression of γ-globin gene and high production of fetal hemoglobin (HbF) in β-thalassemia patients is widely accepted as associated with a milder or even asymptomatic disease. The search for HbF-associated polymorphisms (such as the XmnI,
Bianchi, Nicoletta, Borgatti, Monica, Breveglieri, Giulia, Chiavilli, Francesco, Cosenza, Lucia Carmela, Finotti, Alessia, Gambari, Roberto, Gamberini, MARIA RITA, Lampronti, Ilaria, Montagner, Giulia, Zuccato, Cristina   +10 more
core   +1 more source