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Genetic Analysis of β-Thalassemia Major and β-Thalassemia Intermedia in Brazil

Hemoglobin, 1998
The development of methodologies to identify the molecular lesions responsible for different types of beta-thalassemia has made it possible to correlate these data with clinical and hematological severity. We examined DNA from 35 patients with beta-thalassemia, residents of the State of São Paulo, Brazil, for some types of genetic modifying factors ...
S F, Fonseca, J, Kerbauy, C, Escrivao, M S, Figueiredo, R, Cancado, V R, Arruda, S T, Saad, F F, Costa   +7 more
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Thromboembolic Complications in Beta Thalassemia major

Acta Haematologica, 2009
Thromboembolic complications in β-thalassemia major have seldom been reported and their association with risk factors such as left ventricular failure and postsplenectomy thrombocytosis has remained speculative. In this report we describe 4 patients with unusual thromboembolic manifestations: recurrent arterial occlusion, recurrent pulmonary ...
J, Michaeli, M, Mittelman, D, Grisaru, E A, Rachmilewitz   +3 more
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Cardiopulmonary Assessment in Beta-Thalassemia Major

Chest, 1990
Thalassemia patients succumb at a young age to congestive heart failure. Hitherto, attention has been focused on left ventricular function. This report emphasizes right ventricular dysfunction and abnormal pulmonary function. We performed cardiopulmonary evaluation, including echo-Doppler, spirometry, CO diffusion (DCO), and blood gas analyses in 35 ...
D, Grisaru, E A, Rachmilewitz, M, Mosseri, M, Gotsman, J S, Lafair, E, Okon, A, Goldfarb, Y, Hasin   +7 more
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Immunological Evaluation of Patients with Beta-Thalassemia major

Acta Haematologica, 2001
Abnormalities in the immune system and zinc homeostasis in patients with β-thalassemia major (TM) have been reported. Since zinc ion is essential for the efficiency of the immune system and is required to induce biological activity to thymulin (Zn-FTS), a biochemically defined thymic hormone, we investigated the plasma levels of zinc and both active ...
CONSOLINI, RITA, A. CALLERI, LEGITIMO, ANNALISA, F. MASSEI   +3 more
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Hypoparathyroidism in Beta-Thalassemia major

Acta Haematologica, 2009
In the last 18 years, we have observed 24 cases of hypoparathyroidism (HPT) in β-thalassemia major. At present, 4.5% of patients followed regularly in our department have this complication. HPT is thought to be mainly the consequence of iron deposition in the parathyroid glands. The age of our patients when HPT was diagnosed ranged from 11 to 24 years (
Vincenzo De Satictis, Calogero Vullo, Bruno Bagni, Loretta Chiccoli   +3 more
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Clinical management of [beta ]-thalassemia major

Seminars in Hematology, 2001
Management of patients with beta-thalassemia is based on adequate, safe blood transfusions (free of transfusion-transmitted diseases) and prevention of iron overload. Iron overload causes multiple endocrinopathies, contributes to osteoporosis, and is the cause of cardiac disease.
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Zinc Status in Beta Thalassemia Major Patients

Biological Trace Element Research, 2017
Beta thalassemia is a common monogenic hereditary hemoglobinopathy which is associated with compound complications. Zinc deficiency, which is commonly observed in thalassemia patients, is also associated with multiple health complications. The objective of this study was to determine the zinc status and its effect on the growth and immune functions of ...
Attanayaka Mudiyanselage Dilhara Sewwandi, Karunaratna, Jamburagoda Gamage Shirani, Ranasingha, Rasnayaka Mudiyanselage, Mudiyanse   +2 more
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Choroidal Thickness in Children with Beta Thalassemia Major

Optometry and Vision Science, 2016
ABSTRACT Purpose The purpose of this study was to determine whether there are differences in choroidal thickness in children with beta thalassemia major (β‐TM). Methods Thirty‐five patients with β‐TM and 38 healthy ...
Ali, Simsek, Mehmet, Tekin, Semsettin, Bilak, Ayse Sevgi, Karadag, Capan, Konca, Habip, Almis   +5 more
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Selenium and Glutathione Peroxidase With Beta-Thalassemia Major

Nursing Research, 2001
Chronic iron-overload is a major cause of organ failure and mortality worldwide, but its pathogenesis remains to be elucidated.To examine the relationship between various measures of body iron burden, selenium concentrations and glutathione peroxidase (GPx) activity in patients with beta-thalassemia major.An age- and gender-matched case control study ...
W J, Bartfay, E, Bartfay
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