Results 191 to 200 of about 15,180,142 (299)

Better than Disneyland!

, 2018
The Museum of Skanderborg in Denmark invited everybody who had an interest, to take part in an excavation during the annual autumn school break. The object to be excavated was a poorhouse dating to the end of the 19th century. Usually something like that would not become the object of an excavation, due to its young age.
openaire   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Are two really better than one? A retrospective study comparing monotherapy versus combination therapy for <i>Stenotrophomonas maltophilia</i> infections. [PDF]

Microbiol Spectr
Harris N, Mackowiak A, Wrenn RH, Lee H-J, Reed A, Erkanli A, Turner NA, Moehring R, Deri CR.   +8 more
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Neural networks estimate muscle force in dynamic conditions better than Hill-type muscle models. [PDF]

J Exp Biol
Athanasiadou ME, Daley MA, Koelewijn AD.
europepmc   +1 more source

If two are better than one, three are better than two [PDF]

The Journal of Thoracic and Cardiovascular Surgery, 2018
openaire   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Leukocyte Count Is Better than LDL-C as Predictor of Novel Carotid Atherosclerosis. [PDF]

Biomedicines
Li Y, Cao H, Ding L, Shi X, Naren T, Zhang Q, Wang Z.   +6 more
europepmc   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Does Water Irrigation Control Pleomorphic Adenoma Cell Growth Better Than Saline? [PDF]

OTO Open
Neptune N, Kanchibhatla A, Magliocca KR, Brammer B, Kinney BLC, Kansal V, Boyce BJ, Baddour HM, Schmitt NC.   +8 more
europepmc   +1 more source