Results 111 to 120 of about 139,675 (284)

Temporal Hydrogen‐Bond Network Analysis Reveals Substrate‐Directed Connectivity in Dihydrofolate Reductase

open access: yesProteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Hydrogen‐bond networks are central to protein function, but most network analyses rely on static representations that neglect how interactions evolve in time. Here, we introduce a framework that combines instantaneous and temporal graph analysis of hydrogen‐bond networks derived from molecular dynamics (MD) trajectories to quantify ligand ...
Tandac F. Guclu   +2 more
wiley   +1 more source

The gene “degrees of kevin bacon” (dokb) regulates a social network behaviour in Drosophila melanogaster

open access: yesNature Communications
Social networks are a mathematical representation of interactions among individuals which are prevalent across various animal species. Studies of human populations have shown the breadth of what can spread throughout a social network: obesity, smoking ...
Rebecca Rooke   +6 more
doaj   +1 more source

Approximating Betweenness Centrality

open access: yes, 2008
. Betweenness is a centrality measure based on shortest paths, widely used in complex network analysis. It is computationally-expensive to exactly determine betweenness; currently the fastest-known algorithm by Brandes requires O(nm) time for unweighted ...
David A. Bader   +3 more
core  

Mechanistic Evaluation of Luteolin in Wound Healing of Diabetic Foot Ulcer via Nrf2 Signaling

open access: yesPhytotherapy Research, EarlyView.
Proposed mechanism by which Luteolin (LU) promotes diabetic foot ulcer healing. LU attenuates hyperglycemia‐induced oxidative stress and lipid peroxidation, improves endothelial cell viability, and suppresses ferroptosis through Nrf2‐dependent antioxidant signaling, thereby accelerating angiogenesis and wound repair. ABSTRACT Diabetic foot ulcers (DFUs)
Muhammed Yusuf   +2 more
wiley   +1 more source

Collective Betweenness Centrality in Networks

open access: yesJournal of Multimedia Information System, 2022
Gantulga Gombojav   +2 more
openaire   +2 more sources

Routing Betweenness Centrality Routing Betweenness Centrality

open access: yes, 2020
Betweenness centrality measure is often used in social and computer communication networks to estimate the potential monitoring and control capabilities a vertex may have on data flowing in the network.
Shlomi Dolev   +3 more
core  

Schisandrin C Targets PPARγ to Induce Ferroptosis in Colorectal Cancer Cells and Promote M1 Macrophage Polarization

open access: yesPhytotherapy Research, EarlyView.
Schisandrin C: A Dual Anti‐Colorectal Cancer Strategy Targeting PPARγ. ABSTRACT Colorectal cancer (CRC) remains a leading cause of cancer mortality, necessitating novel therapeutic strategies. Schisandrin C (SinC), a bioactive lignan from Schisandra chinensis, exhibits diverse pharmacological activities, but its anti‐CRC mechanisms are poorly ...
Xiao Wei   +4 more
wiley   +1 more source

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