Results 211 to 220 of about 55,464 (281)

Mechanism‐Aware Deep Learning Maps the Redox Landscape of Cancer‐Relevant Antioxidants

open access: yesChemistry–Methods, Volume 6, Issue 4, April 2026.
A mechanism‐aware deep learning framework links chemical structure to redox biology, enabling pathway‐specific prediction of antioxidant mechanisms across six core reactive oxygen species‐regulatory systems and outperforming structure‐only baseline by learning biologically grounded rather than purely chemical similarity rules.
Shiva Satija   +2 more
wiley   +1 more source

The Small Molecule Compound Eupalinolide B Ameliorates Depressive Behaviors and Neuropathic Pain in Mice With Spared Nerve Injury: Integrating Network Pharmacology, Molecular Docking, Bioinformatics, Molecular Dynamics Simulation and Experimental Verification

open access: yesCNS Neuroscience &Therapeutics, Volume 32, Issue 4, April 2026.
Through network pharmacology, molecular docking, molecular dynamics simulations, and bioinformatics techniques, three potential core targets of EB for the treatment of pain‐depression comorbidity (EGFR, PTGS2, and JUN) were identified. Subsequent animal studies demonstrated that EB alleviates pain and depression‐like behaviors by inhibiting glial cell ...
Xuesong Yang   +4 more
wiley   +1 more source

A Review of Vagus Nerve Stimulation for Disease: Comprehensive Theory and Evidence for Mechanisms of Action

open access: yesComprehensive Physiology, Volume 16, Issue 2, April 2026.
Vagus nerve stimulation (VNS) effects span central and peripheral organ systems through diverse mechanistic pathways. This comprehensive review provides a unified synthesis of these mechanisms across neurological, cardiovascular, immunological, metabolic, and gastrointestinal domains, filling a critical gap and serving as a foundational resource for ...
Yifeng Bu   +11 more
wiley   +1 more source

Abnormal intrinsic brain functional network dynamics in patients with postherpetic neuralgia. [PDF]

open access: yesFront Neurol
You Y   +9 more
europepmc   +1 more source

Integrated multi‐regional multiomic profiling of breast phyllodes tumours reveals peritumoural immune activation and stromal remodelling

open access: yesClinical and Translational Medicine, Volume 16, Issue 4, April 2026.
Malignant phyllodes tumours show markedly higher proliferative activity than benign and borderline tumours. Malignant phyllodes display an immune activated peritumoural region but an immune excluded tumour core. In malignant cases, a more pronounced immune segregation phenotype may be associated with a lower risk of recurrence.
Tian‐Qi Gu   +8 more
wiley   +1 more source

‘MultiTraits': an integrated R package for analysis and visualization of multidimensional plant traits

open access: yesEcography, Volume 2026, Issue 4, April 2026.
The multidimensional characteristics of plant traits and their trade‐offs are central to ecology. However, there is a lack of systematic and standardized tools for analyzing these intricate relationships. To fill this gap, we developed the ‘MultiTraits' R package, which incorporates four complementary analytical modules: competitors–stress tolerators ...
Yan He   +3 more
wiley   +1 more source

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