Results 41 to 50 of about 52,647 (260)

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

open access: yesFEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu   +5 more
wiley   +1 more source

5G and Beyond [PDF]

open access: yesJournal of the Indian Institute of Science, 2020
Chandra R. Murthy, Rajesh Sundaresan
openaire   +2 more sources

Efficient Power Control Framework for Small-Cell Heterogeneous Networks

open access: yesSensors, 2020
Heterogeneous networks are rapidly emerging as one of the key enablers of beyond fifth-generation (5G) wireless networks. It is gradually becoming clear to the network operators that existing cellular networks may not be able to support the traffic ...
Qais Alsafasfeh   +5 more
doaj   +1 more source

Enhanced Paging Monitoring for 5G and Beyond 5G Networks

open access: yesIEEE Access, 2022
User experience, characterized by not only data rate and latency but also power consumption, is one of the major drivers for the success of 5G and Beyond-5G (B5G) networks.
Anil Agiwal, Mamta Agiwal
doaj   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

open access: yesFEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold   +11 more
wiley   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

open access: yesFEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li   +8 more
wiley   +1 more source

Integrating AI in security information and event management for real time cyber defense

open access: yesScientific Reports
The increasing frequency and sophistication of cyber-attacks have exposed significant shortcomings in conventional detection systems, emphasizing the urgent need for more advanced Cyber Threat Intelligence (CTI) capabilities.
Salman Khan   +4 more
doaj   +1 more source

Beyond 5G. Strategic Pathways to 6G Development and Emerging Applications [PDF]

open access: yesIranian Journal of Information Processing & Management
Background: The rapid evolution from 4G to 5G has transformed the telecommunications landscape, but as technological demands continue to grow, the shift toward 6G is gaining attention.
Mohammed Abdul Jaleel Maktoof   +4 more
doaj   +1 more source

Optical Technology for NFV Converged Networks

open access: yesApplied Sciences, 2021
5G and its evolution towards 6G is unlocking new use cases that will require the reconsideration of the existing network architectures and its operation.
Paola Iovanna   +6 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

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