Results 1 to 10 of about 19,322,556 (301)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
, 2018 We discuss the status of the Standard Model (SM): the principles; the Lagrangian; the problems; open questions and the ways beyond. Then we consider possible physics beyond the SM: New symmetries (Gauge, SUSY); New particles (gauge, axion, superpartners); New dimensions (extra, large, compact, etc) or a New Paradigm (strings, branes, gravity).
openaire +2 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Saxion cosmology for thermalized gravitino dark matter
Journal of High Energy Physics, 2017 In all supersymmetric theories, gravitinos, with mass suppressed by the Planck scale, are an obvious candidate for dark matter; but if gravitinos ever reached thermal equilibrium, such dark matter is apparently either too abundant or too hot, and is ...
Raymond T. Co +3 more
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Detecting dark matter with Aharonov-Bohm
Journal of High Energy Physics, 2019 While the evidence for dark matter continues to grow, the nature of dark matter remains a mystery. A dark U(1) D gauge theory can have a small kinetic mixing with the visible photon which provides a portal to the dark sector.
John Terning, Christopher B. Verhaaren
doaj +1 more source
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Baryogenesis, dark matter, and flavor structure in non-thermal moduli cosmology
Journal of High Energy Physics, 2019 The appearance of scalar/moduli fields in the early universe, as motivated by string theory, naturally leads to non-thermal “moduli cosmology”. Such cosmology provides a consistent framework where the generation of radiation, baryons, and dark matter can
Mu-Chun Chen, Volodymyr Takhistov
doaj +1 more source