Results 71 to 80 of about 3,618,801 (299)

Circulating tumor cells in metastatic breast cancer patients treated with immune checkpoint inhibitors – a biomarker analysis of the ALICE and ICON trials

Molecular Oncology, EarlyView.
In this explorative biomarker analysis, we assessed serial sampling of circulating tumor cells (CTCs) with CellSearch in two randomized trials testing immune checkpoint inhibitors (ICIs) in metastatic breast cancer. Our data demonstrate a prognostic potential of CTCs, most apparent 4 weeks into ICI therapy.
Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Elin Borgen, Cecilie Bendigtsen Schirmer, Bjørnar Gilje, Øystein Garred, Jon Lømo, Marius Stensland, Oddmund Nordgård, Ragnhild Sørum Falk, Randi R. Mathiesen, Hege G. Russnes, Jon Amund Kyte, Bjørn Naume   +13 more
wiley   +1 more source

Road map through the desert: unification with vector-like fermions

Journal of High Energy Physics, 2019
In light of null results from New Physics searches at the LHC, we look at unification of the gauge couplings as a model-building principle. As a first step, we consider extensions of the Standard Model with vector-like fermions.
Kamila Kowalska, Dinesh Kumar
doaj   +1 more source

Families from supergroups and predictions for leptonic CP violation

Journal of High Energy Physics, 2017
As was shown in 1984 by Caneschi, Farrar, and Schwimmer, decomposing representations of the supergroup SU(M |N ), can give interesting anomaly-free sets of fermion representations of SU(M ) × SU(N ) × U(1).
S. M. Barr, Heng-Yu Chen
doaj   +1 more source

Yukawa ratio predictions in non-renormalizable SO(10) GUT models

Journal of High Energy Physics, 2020
Since SO(10) GUTs unify all fermions of the Standard Model plus a right-chiral neutrino in a representation 16 per family, they have the potential to be maximally predictive regarding the ratios between the masses (or Yukawa couplings) of different ...
Stefan Antusch, Christian Hohl, Vasja Susič   +2 more
doaj   +1 more source

Magnetogenesis from a rotating scalar: à la scalar chiral magnetic effect

Journal of High Energy Physics, 2020
The chiral magnetic effect (CME) is a phenomenon in which an electric current is induced parallel to an external magnetic field in the presence of chiral asymmetry in a fermionic system.
Kohei Kamada, Chang Sub Shin
doaj   +1 more source

Circulating tumor cells: advancing personalized therapy in small cell lung cancer patients

Molecular Oncology, EarlyView.
Small cell lung cancer (SCLC) is an aggressive form of lung cancer that spreads rapidly to secondary sites such as the brain and liver. Cancer cells circulating in the blood, “circulating tumor cells” (CTCs), have demonstrated prognostic value in SCLC, and evaluating biomarkers on CTCs could guide treatment decisions such as for PARP inhibitors ...
Prajwol Shrestha, Steven Kao, Veronica K. Cheung, Wendy A. Cooper, Nico van Zandwijk, John E. J. Rasko, Dannel Yeo   +6 more
wiley   +1 more source

Physics Beyond the Standard Model

, 2009
I present a brief overview of some exciting possibilities for physics Beyond the Standard Model. I include short discussions of neutrino physics, the strong CP problem and axions, GUTs, large and warped extra dimensions, Little Higgs models and ...
Howard Baer, Marvin L. Marshak
core   +1 more source

b Physics Beyond the Standard Model [PDF]

, 2002
I review the signals for New Physics in CP-violating measurements in B and Lambda_b decays. I also discuss ways of identifying this New Physics, should such a signal be found.Comment: 10 pages, LaTeX, 1 figure, ps file included.
Abe, Albajar, Aleksan, Aleksan, Aleksan, Ali, Ali, Atwood, Atwood, Barenboim, Bensalem, Bensalem, Branco, Buchalla, Datta, David London, Dunietz, Fleischer, Fleischer, Gronau, Gronau, Gronau, Gronau, Gronau, Gronau, Gronau, Gronau, Grossman, Hiller, Hoecker, Hou, Leroux, London, London, London, Nir, Scares, Silva, Wolfenstein   +38 more
core   +2 more sources

Integrative transcriptomic analysis identifies emetine as a promising candidate for overcoming acquired resistance to ALK inhibitors in lung cancer

Molecular Oncology, EarlyView.
We propose an efficient strategy to suppress ALK inhibitor (ALKi) resistance. By analyzing transcriptome data, we identified emetine as a potential inhibitor. We demonstrated that emetine exhibited effectiveness in inhibiting the growth of ALKi‐resistant cells, and further interpreted its impact on the resistant signatures through drug‐induced RNA ...
Sang‐Min Park, Keeok Haam, Haejeong Heo, Doyeong Kim, Min‐Ju Kim, Hyo‐Jung Jung, Seongwon Cha, Mirang Kim, Haeseung Lee   +8 more
wiley   +1 more source

Running of fermion observables in non-supersymmetric SO(10) models

Journal of High Energy Physics, 2018
We investigate the complete renormalization group running of fermion observables in two different realistic non-supersymmetric models based on the gauge group SO(10) with intermediate symmetry breaking for both normal and inverted neutrino mass orderings.
Tommy Ohlsson, Marcus Pernow
doaj   +1 more source