Сardioprotective agents with biaromatic structure. Part 3. Sodium channel blockers [PDF]
Фармакокинетика и Фармакодинамика, 2022 This review continues a series of reviews on the analysis of compounds with cardioprotective properties in a number of biaromatic structures, which include a range of sodium channel blockers. Among voltage-gated sodium channels, the Nav1.5 isoform is the
G. V. Mokrov
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Pd Nanoparticles Immobilized on Pyridinic N-Rich Carbon Nanosheets for Promoting Suzuki Cross-Coupling Reactions [PDF]
NanomaterialsPalladium (Pd) catalysts play a crucial role in facilitating Suzuki cross-coupling reactions for the synthesis of valuable organic compounds. However, conventional heterogeneous Pd catalysts often encounter challenges such as leaching and deactivation ...
Shihao Cui +7 more
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Сardioprotective agents with biaromatic structure. Part 2. HCN channel blockers [PDF]
Фармакокинетика и Фармакодинамика, 2022 Hyperpolarization-activated cyclic nucleotide–gated (HCN) channels, primarily their HCN4 subtype, are one of the promising targets for the development of cardioprotective agents.
G. V. Mokrov
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Сardioprotective agents with biaromatic structure. Part 6. Beta blockers [PDF]
Фармакокинетика и Фармакодинамика, 2023 β-Blockers are one of the oldest classes of cardioprotectors used in the treatment of cardiovascular diseases. They reduce the heart rate, have a hypotensive effect, inhibit myocardial contractility and have antiarrhythmic properties.
G. V. Mokrov
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Сardioprotective agents with biaromatic structure. Part 1. Calcium channel blockers [PDF]
Фармакокинетика и Фармакодинамика, 2022 Cardiovascular diseases (CVD) are widespread and the leading cause of morbidity and mortality worldwide. Drugs for the treatment of CVD have been developed since the beginning of the 20th century.
G. V. Mokrov
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Сardioprotective agents with biaromatic structure. Part 5. Potassium Kv1.5-channels blockers [PDF]
Фармакокинетика и Фармакодинамика, 2023 The Kv1.5 potassium channel provides an ultra-rapid delayed rectifier potassium current, IKur, that acts selectively in human atrial cells. This makes selective Kv1.5 blockade a promising approach to control atrial arrhythmias without the adverse ...
G. V. Mokrov
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Focus on Human Monoamine Transporter Selectivity. New Human DAT and NET Models, Experimental Validation, and SERT Affinity Exploration. [PDF]
ACS Chem Neurosci, 2020 The most commonly used antidepressant drugs are the serotonin transporter inhibitors. Their effects depend strongly on the selectivity for a single monoamine transporter compared to other amine transporters or receptors, and the selectivity is roughly ...
Ortore G +6 more
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Metabolic Value Chemoattractants Are Preferentially Recognized at Broad Ligand Range Chemoreceptor of Pseudomonas putida KT2440. [PDF]
Front Microbiol, 2017 Bacteria have evolved a wide range of chemoreceptors with different ligand specificities. Typically, chemoreceptors bind ligands with elevated specificity and ligands serve as growth substrates.
Fernández M +3 more
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HbpR, a new member of the XylR/DmpR subclass within the NtrC family of bacterial transcriptional activators, regulates expression of 2-hydroxybiphenyl metabolism in Pseudomonas azelaica HBP1. [PDF]
J Bacteriol, 2000 The regulation of 2-hydroxybiphenyl and 2,2′-dihydroxybiphenyl degradation in Pseudomonas azelaica is mediated by the regulatory gene, hbpR .
Jaspers MC +5 more
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Deep learning-driven neuromorphogenesis screenings identify repurposable drugs for mitochondrial disease [PDF]
Mitochondrial disease encompasses untreatable conditions affecting tissues with high energy demands. A severe manifestation of mitochondrial disease is Leigh syndrome (Leigh), which causes defects in basal ganglia and midbrain regions, psychomotor ...
Menacho C +30 more
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