Analysis of original bis-arylazaazkanes derivatives compliance with the calculated pharmacophoric models of biaromatic ligands of cardioprotective drugs biotargets [PDF]
Eight important biotargets of biaromatic cardioprotective drugs were selected in this work: calcium Cav1.2-channel, sodium Nav1.5-channel, potassium hERG-channel and Kv1.5-channel, HCN-channel, β1-adrenergic receptor, ryanodine RyR2-receptor and σ1 ...
A. S. Pantileev +5 more
core +2 more sources
Bioavailability of pollutants and chemotaxis [PDF]
, 2013 The exposure of bacteria to pollutants induces frequently chemoattraction or chemorepellent reactions. Recent research suggests that the capacity to degrade a toxic compound has co-evolved in some bacteria with the capacity to chemotactically react to it.
Jimenez-Sanchez, Celia +5 more
core +2 more sources
Enhanced removal of 8-quinolinecarboxylic acid in an activated carbon cloth by electroadsorption in aqueous solution [PDF]
, 2016 The effect of the electrochemical treatment (potentiostatic treatment in a filter-press electrochemical cell) on the adsorption capacity of an activated carbon cloth (ACC) was analyzed in relation with the removal of 8-quinolinecarboxylic acid pollutant ...
López-Bernabeu, S. +4 more
core +2 more sources
A comparative assessment of modern cyclization methods of substituted alkynyl esters, ethers, and acids [PDF]
, 2017 Naturally occurring heterocycles such as pyrones, dihydropyrones, and isocoumarins have proven to be highly active biological agents with a vast plethora of applications. Therefore, their synthesis has attracted mentionable notice in recent decades.
Melen, Rebecca +2 more
core +2 more sources
DESIGN, SYNTHETIC APPROACHES, BIOPHARMACOLOGICAL INVESTIGATION, AND STRUCTURE ACTIVITY RELATIONSHIPS OF NOVEL LIGANDS TARGETING NEURONAL NICOTINIC RECEPTOR SUBTYPES [PDF]
, 2013 In the central nervous system (CNS), ligand-gated ion channels can be found presynaptically, in nerve terminals, where they control neurotransmitter release. Among them, neuronal nicotinic acetylcholine receptors (nAChRs) constitute a particular example,
D.Y. Pome&apos
core +1 more source
Entwicklung und Anwendung von Kernspinresonanz-Spektroskopie und Röntgenkristallographie in früher Wirkstoffentwicklung [PDF]
, 2020 Challenges in drug discovery including difficulties obtaining structural information on the ligand-protein complex are approached using multiple methods.
Softley, Charlotte
core
Relationships between Inhibition, Transport and Enhanced Transport via the Organic Cation Transporter 1. [PDF]
Int J Mol Sci, 2022 Jensen O +3 more
europepmc +1 more source
Avoiding Adverse Effects: New Ideas in Drug Discovery for Targeting PPARγ [PDF]
, 2019 Peroxisome proliferator-activated receptor gamma (PPARγ) has been a drug target to treat type 2 diabetes for the last 20 years when rosiglitazone and pioglitazone were approved by the FDA in 1999.
Patton, Trey M
core +1 more source
Design and synthesis of unique indole-benzosulfonamide oleanolic acid derivatives as potent antibacterial agents against MRSA. [PDF]
The rapid emergence of antibiotic resistance and the scarcity of novel antibacterial agents have necessitated an urgent pursuit for the discovery and development of novel antibacterial agents against multidrug-resistant bacteria.
Ang, Song +14 more
core +1 more source
Asymmetric Synthesis of Axially Chiral Molecules via Organocatalytic Cycloaddition and Cyclization Reactions. [PDF]
Molecules, 2023 Cai WY, Ding QN, Zhou L, Chen J.
europepmc +1 more source