Results 91 to 100 of about 6,599,728 (380)

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

Variable Bias Coin Tossing

, 2005
Alice is a charismatic quantum cryptographer who believes her parties are unmissable; Bob is a (relatively) glamorous string theorist who believes he is an indispensable guest.
A. Ambainis, Adrian Kent, C. Crépeau, C. H. Bennett, C. W. Helstrom, D. Aharonov, G. Brassard, Roger Colbeck   +7 more
core   +1 more source

Attention bias dynamics and symptom severity during and following CBT for social anxiety disorder [PDF]

, 2016
Objective: Threat-related attention bias figures prominently in contemporary accounts of the maintenance of anxiety disorders, yet longitudinal intervention research relating attention bias to anxiety symptom severity is limited.
Beevers, CG, Bernstein, A, Davis, ML, Koster, Ernst, Reinecke, A, Rosenfield, D, Smits, JAJ, Zvielli, A   +7 more
core   +2 more sources

Bias in research [PDF]

Biochemia Medica, 2013
By writing scientific articles we communicate science among colleagues and peers. By doing this, it is our responsibility to adhere to some basic principles like transparency and accuracy. Authors, journal editors and reviewers need to be concerned about the quality of the work submitted for publication and ensure that only studies which have been ...
openaire   +3 more sources

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

The Interest in Nanomaterials for Topical Photoprotection

Cosmetics, 2015
Wearing clothes and using sun protection products are effective ways of preventing non-melanocytic skin cancer. Sun protection products are classified as cosmetics in Europe.
Céline Couteau, Laurence Coiffard
doaj   +1 more source

PROBAST: A Tool to Assess the Risk of Bias and Applicability of Prediction Model Studies

Annals of Internal Medicine, 2019
Prediction relates to estimating the probability of something currently unknown. In the context of medical research, prediction typically concerns either diagnosis (probability of a certain condition being present but not yet detected) or prognosis ...
R. Wolff, K. Moons, R. Riley, P. Whiting, M. Westwood, G. Collins, J. Reitsma, J. Kleijnen, S. Mallett   +8 more
semanticscholar   +1 more source

Kinerja Aplikasi Client Server untuk Sistem Informasi Tumbuh Kembang Balita [PDF]

, 2014
Pada saat ini aplikasi web merupakan sumber untuk mencari informasi secara modern yang berkembang sangat cepat. Dalam pembuatan aplikasi web tidak hanya sisi desain dan informasi yang perlu diperhatikan tetapi dalam aspek keamanan dan kinerja dari ...
, Endah Sudarmilah, S.T., M.Eng, Giyanisis, Bias   +1 more
core  

Landscape of BRAF transcript variants in human cancer

Molecular Oncology, EarlyView.
We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda, Danilo Tatoni, Gianluca Mattei, Alberto Magi, Romina D'Aurizio, Laura Poliseno   +5 more
wiley   +1 more source

Fast simulation of the influence of a refractive free-form microstructure on a wave field based on scalar diffraction theory

Journal of the European Optical Society-Rapid Publications
We present a novel fast simulation approach to simulate the influence of refractive freeform microstructures on a wave field. The FRISP (Finite Refractive Index Selective Propagation) method combines the Rayleigh-Sommerfeld diffraction integral with a ...
Thiemicke Fabian, El-Bashar Ramy, Hameed Mohamed F.M., Agour Mostafa, Obayya Salah S.A., Bergmann Ralf B., Falldorf Claas   +6 more
doaj   +1 more source