Results 91 to 100 of about 3,138,949 (312)
, 2023 Full Changelog: https://github.com/alondmnt/codon-bias/compare/0.3.0...v0.3.
Alon Diament
core +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
A generic algorithm for reducing bias in parametric estimation [PDF]
, 2010 A general iterative algorithm is developed for the computation of reduced-bias parameter estimates in regular statistical models through adjustments to the score function.
Firth, David +3 more
core +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Full-field imaging of guided ultrasonic wave fields using lensless digital holography
Journal of the European Optical Society-Rapid PublicationsIn this work, we present the full-field measurement of guided ultrasonic waves (GUWs) on technical surfaces using lensless digital holography. The setup works with a pulsed coherent laser illumination and a complementary metal-oxide semiconductor (CMOS ...
Gutiérrez-Cañas Pazos Beñat +7 more
doaj +1 more source
Effect of Publication Bias on Retrieval Bias
Academic Medicine, 2002 Publication bias is the main etiologic factor in retrieval bias. The authors measured the influence a positive study outcome had on housestaff's selecting the study for presentation.
Craig E, Daniels +2 more
openaire +3 more sources
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Journal of the European Optical Society-Rapid PublicationsWe present a novel fast simulation approach to simulate the influence of refractive freeform microstructures on a wave field. The FRISP (Finite Refractive Index Selective Propagation) method combines the Rayleigh-Sommerfeld diffraction integral with a ...
Thiemicke Fabian +6 more
doaj +1 more source
The Interest in Nanomaterials for Topical Photoprotection
Cosmetics, 2015 Wearing clothes and using sun protection products are effective ways of preventing non-melanocytic skin cancer. Sun protection products are classified as cosmetics in Europe.
Céline Couteau, Laurence Coiffard
doaj +1 more source