Results 91 to 100 of about 304,459 (351)
PLoS ONE, 2019 Estimating a predictive model from a dataset is best initiated with an unbiased estimator. However, since the unbiased estimator is unknown in general, the problem of the bias-variance tradeoff is raised.
Jeongwoo Kim
doaj +1 more source
Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays
FEBS Open Bio, EarlyView.We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul +3 more
wiley +1 more source
Estimation of Nonresponse Bias [PDF]
Sociological Methods & Research, 1975 An imputation procedure is used to estimate the effects of nonresponse on issues of substantive interest in a social survey. Using this method, one can determine that nonresponse bias may have differential effects on variable means, depending on the combination of independent variables used in the ensuing substantive analysis of data from the survey.
openaire +2 more sources
Molecular determinants of signal transduction in tropomyosin receptor kinases
FEBS Open Bio, EarlyView.Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley +1 more source
An assessment of three variance estimators for the k-nearest neighbour technique
Silva Fennica, 2013 A jackknife (JK), a bootstrap (BOOT), and an empirical difference estimator (EDE) of totals and variance were assessed in simulated sampling from three artificial but realistic complex multivariate populations (Nâ=â8000 elements) organized in ...
Magnussen, Steen
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FEBS Open Bio, EarlyView.Comparative analysis of chloroplast genomes from 14 genera of Thymelaeaceae revealed variation in gene content, ranging from 128 to 142 genes, primarily influenced by IR expansion/contraction events and pseudogenization of ndhF, ndhI, and ndhG. Two large inversions were detected within the large single‐copy region, including a synapomorphic inversion ...
Abdullah +8 more
wiley +1 more source
Demystifying Fixed k-Nearest Neighbor Information Estimators
, 2016 Estimating mutual information from i.i.d. samples drawn from an unknown joint density function is a basic statistical problem of broad interest with multitudinous applications.
Gao, Weihao +2 more
core +1 more source
EXACT BIAS OF ESTIMATOR FOR UAR(1) MODEL WITH MISSING OBSERVATIONS
, 2022 Mahmoud M. Abdelwahab
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FEBS Open Bio, EarlyView.This study addressed how a senior research thesis is perceived by undergraduate students. It assessed students' perception of research skills, epistemological beliefs, and career goals in Biochemistry (science) and BDC (science‐business) students. Completing a thesis improved confidence in research skills, resilience, scientific identity, closed gender‐
Celeste Suart +4 more
wiley +1 more source
Efficient GMM Estimation of Dynamic Panel Data Models Where Large Heterogeneity May Be Present [PDF]
This paper addresses the many instruments problem, i.e. (1) the trade-off between the bias and the efficiency of the GMM estimator, and (2) inaccuracy of inference, in dynamic panel data models where unobservable heterogeneity may be large.
Kazuhiko Hayakawa
core