Results 211 to 220 of about 12,927,750 (273)

Single‐Cell Profiling Reveals a Protective WNT5A‐ATF3‐FOSB Signaling Axis in Hair Follicle Stem Cells During Androgenetic Alopecia

open access: yesAdvanced Science, EarlyView.
Androgenetic alopecia (AGA) is a common form of hair loss with limited treatment options. Silencing of WNT5A signaling, which is widely known as the trigger of the ncWNT signaling pathway, happens in hair follicle stem cells from balding areas. It leads to downregulation of ATF3 and its target FOSB.
Ruiyu Luo   +10 more
wiley   +1 more source

3D Printed Meter‐Scale Soft Origami Robots Capable of Load‐Bearing Actuation Via Crease Stiffness Modulation

open access: yesAdvanced Science, EarlyView.
Origami has inspired numerous soft deployable mechanisms for safe human‐robot interaction, while its intrinsic kinematic instability at arbitrary configurations limited their practical robotic application. This work presents a 3D printed meter‐scale origami robotic actuator capable of load‐bearing deformation through creaseline stiffness modulation.
Sung Yol Yu   +5 more
wiley   +1 more source

Blue or gold? Visual perception and the restoration of a Medieval painting. [PDF]

open access: yesPerception
van Gelderen FA   +4 more
europepmc   +1 more source

Nucleoside‐Modified mRNA Encoding Alpha‐Galactosidase A Ameliorates Fabry Disease Phenotypes in Human IPSC‐Derived Cardiomyocytes

open access: yesAdvanced Science, EarlyView.
Human iPSC‐derived Fabry cardiomyocytes exhibited broad transcriptional dysregulation, apoptosis, mitochondrial dysfunction, impaired reactive oxygen species handling, altered contractility, and abnormal calcium transient decay, potentially mediated by phospholamban hyperphosphorylation.
Malte Juchem   +24 more
wiley   +1 more source

Perceived Time Shapes Physical Fatigue Accumulation and Its Neural Oscillatory Correlates

open access: yesAdvanced Science, EarlyView.
Can a clock change the course of physical fatigue? By covertly manipulating the clock calibration during repeated isometric contractions, we showed that perceived time shapes fatigue accumulation and frontal oscillatory dynamics. While fatigue accumulation was only reduced when the clock was slowed down, frontal oscillatory dynamics followed perceived ...
Pierre‐Marie Matta   +3 more
wiley   +1 more source

Learning Work Function via Implicit Reasoning on Electrostatic Potential Landscapes

open access: yesAdvanced Science, EarlyView.
StructPot‐CLR establishes a cross‐modal contrastive learning framework that aligns the crystal structures of 2D materials with plane‐averaged electrostatic potential landscapes for physically informed work‐function prediction. The model achieves an MAE of 0.265 eV and an R2 of 0.902 on the held‐out test set while accurately preserving key morphological
Haoyu Wan, Yue Wu, Tianhao Su, Deng Pan
wiley   +1 more source

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