Results 321 to 330 of about 1,012,533 (359)

SCORT–Cas13d Nanotherapy Precisely Targets the ‘Undruggable’ Transcription Factor HoxB13 in Metastatic Prostate Cancer In Vivo

Advanced Science, EarlyView.
SCORT–Cas13d–pre‐gHoxB13 lipid nanoparticles precisely deliver Cas13d mRNA and guide RNAs to metastatic prostate tumors in the liver, knocking down the “undruggable” transcription factor HoxB13. This approach suppresses metastatic tumor growth, extends mouse survival, and does not induce major organ toxicity or immune activation, offering a safe and ...
Zhifen Cui, Furong Huang, Kun Fang, Jingyue Yan, Yuebao Zhang, Diana D. Kang, Yufan Zhou, Yue Zhao, Jeffrey I. Everitt, William Hankey, Andrew J Armstrong, Jiaoti Huang, Hongyan Wang, Victor X. Jin, Yizhou Dong, Qianben Wang   +15 more
wiley   +1 more source

PABPN1 Couples the Polyadenylation and Translation of Maternal Transcripts to Mouse Oocyte Meiotic Maturation

Advanced Science, EarlyView.
This study reveals that cytoplasmic PABPN1 is essential for mouse oocyte meiotic maturation by coordinating polyadenylation, translation, and degradation of maternal mRNAs. Pabpn1 knockout disrupts CDK1 activation, spindle formation, and chromosome alignment by impairing maturation‐promoting factor (MPF) regulation and BTG4‐mediated deadenylation ...
Xing‐Xing Dai, Yu‐Ke Wu, Shuai‐Bo Pi, Feng‐Jie Hu, Yun‐Wen Wu, Hang Qi, Zhiyi Li, Zhi‐Yan Jiang, Long‐Wen Zhao, Heng‐Yu Fan   +9 more
wiley   +1 more source

Collaboration, Compilation, and Confession in Folger MS E.a.1. [PDF]

Reformation
McCarthy EA.
europepmc   +1 more source

SHORT HISTORY OF OBESITY. [PDF]

Acta Endocrinol (Buchar)
Micic D, Polovina S, Micic D, Yumuk VD.
europepmc   +1 more source

Beta Test of a Christian Faith-Based Facebook Intervention for Smoking Cessation in Rural Communities (FaithCore): Development and Usability Study. [PDF]

JMIR Form Res
Sharma P, Tranby B, Kamath C, Brockman TA, Lenhart N, Quade B, Abuan N, Halom M, Staples J, Young C, Brewer L, Patten C.   +11 more
europepmc   +1 more source

Indonesian Christian nurses' perspectives on peaceful death: A qualitative study. [PDF]

Belitung Nurs J
Sitanggang YF, Juniarta, Fangidae E.
europepmc   +1 more source

Poor prognostic factors and unmet needs in rheumatoid arthritis. [PDF]

Rheumatology (Oxford)
Smolen JS.
europepmc   +1 more source

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The Frankenstein of Biblical Studies?

Expositions, 2015
Advances in archaeology and carbon-dating contribute to our understanding of the biblical text's historical context, of daily life in ancient Israel, and of the provenance of inscriptions. All of this information (seemingly) makes us better readers of the text with greater understanding of the text's context, but does it?
openaire   +2 more sources

Etymological Studies in Biblical Hebrew

Vetus Testamentum, 1952
primarily on account of the change of person in the last word. Hence no doubt the Septuagint, Peshitta, and Targum Onkelos felt constrained to read nbt on a par with the second person of the first verb. Jewish tradition, adhering to the Masoretic text, is compelled to resort to a desperate remedy, namely breaking up the brief clause into two ...
openaire   +2 more sources