Results 71 to 80 of about 134,978 (240)

Evolving Surgical Approaches to Bicuspid Aortic Valve Associated Aortopathy

Frontiers in Cardiovascular Medicine, 2019
Bicuspid aortic valve (BAV) is the most common congenital cardiac pathology which results from the fusion of two adjacent aortic valve cusps. It is associated with dilatation of the aorta, known as bicuspid valve-associated aortopathy or bicuspid ...
Ali Fatehi Hassanabad, Christopher M. Feindel, Subodh Verma, Paul W. M. Fedak, Paul W. M. Fedak   +4 more
doaj   +1 more source

The Relationship between Arterial Elasticity Parameters of Ascending Aorta, Abdominal Aorta and Carotid Arteries with Carotid Intima Media Thickness in Children with Bicuspid Aortic Valve

Anatolian Journal of Cardiology, 2022
Background: Bicuspid aortic valve is a congenital cardiac malformation that affects not only the valve and ascending aorta but also the abdominal aorta and large central arteries like carotid arteries by damaging the elasticity of the vessel resulting in
Ajda Mutlu Mıhçıoğlu, Feyza Paç, Muharrem Tola, Ahmet Vedat Kavurt, Serhat Koca, Denizhan Bağrul   +5 more
doaj   +1 more source

Prevalence and Spectrum of Congenital Heart Disease in Individuals With Distal Chromosome 22q11.22–23 Deletions

Clinical Genetics, EarlyView.
The frequency and severity of congenital heart disease vary extensively in individuals with 22q11.22–23 distal deletions. Reduced gene dosage particularly within the low copy repeat (LCR22) D–E region including MAPK1 and HIC2 conveys risk for these defects.
Tanner J. Nelson, Daniel E. McGinn, T. Blaine Crowley, Lydia Rockart, Audrey Green, Victoria Giunta, Oanh Tran, Daniella Miller, Jeroen Breckpot, Ann Swillen, M. Cristina Digilio, Marta Unolt, Carolina Putotto, Federica Pulvirenti, Bruno Marino, Beverly S. Emanuel, Elaine H. Zackai, Zhengdong D. Zhang, Elizabeth Goldmuntz, Erik Boot, Anne S. Bassett, Bernice E. Morrow, Donna M. McDonald‐McGinn   +22 more
wiley   +1 more source

Variability of repairable bicuspid aortic valve phenotypes: towards an anatomical and repair-oriented classification.

European Journal of Cardio-Thoracic Surgery, 2019
OBJECTIVES: The bicuspid aortic valve (BAV) exists in a wide variety of valve phenotypes. The aim of this study was to assess the anatomical characteristics of the different phenotypes and develop a classification system to aid surgical repair. METHODS:
L. de Kerchove, S. Mastrobuoni, L. Froede, S. Tamer, M. Boodhwani, M. V. Van Dyck, G. El Khoury, H. Schäfers   +7 more
semanticscholar   +1 more source

Unraveling the Trio of Interrupted Descending Aorta, Aortic Stenosis, and Bicuspid Aortic Valve: A Complex Cardiovascular Conundrum [PDF]

, 2023
Saket Toshniwal, Gajendra Agrawal, Anuj Chaturvedi, Akash Lohakare, Sunil Kumar   +4 more
openalex   +1 more source

Transcatheter intervention for ruptured sinus of Valsalva aneurysm and coarctation of aorta with bicuspid aortic valve

IHJ Cardiovascular Case Reports, 2022
Ruptured sinus of Valsalva aneurysm (RSVA) is a rare entity. Its association with severe coarctation of aorta (CoA) in the setting of bicuspid aortic valve is very rare. We hereby report simultaneous transcatheter device closure of RSVA and coarctoplasty
Rajdatt A. Deore, Murugesh S. Hiremath
doaj   +1 more source

Dimerization‐dependent NOTCH receptor transactivation unveils a class of highly selective NOTCH signalling inhibitors

The FEBS Journal, EarlyView.
NOTCH signalling is indispensable for tissue homeostasis and, consequently, corruption of its normal function promotes numerous diseases, including cancer. However, the development of targeted therapies has been hampered by inefficacy and overt toxicity. Here, we show that NOTCH receptor dimerization is necessary for receptor transactivation, which has
Xinxin Liu, Haijiang Wang, Gunja Mishra, Lin‐Ting Wu, Chao Li, Maarten van Dinther, Jin Liu, Manuel A.F.V. Gonçalves, Peter ten Dijke, David A. Baker   +9 more
wiley   +1 more source

Cyclin‐dependent kinase 13 is indispensable for normal mouse heart development

Journal of Anatomy, Volume 246, Issue 4, Page 616-630, April 2025.
Congenital heart disease (CHD) is the most common defect in live births. The role of cyclin‐dependent kinase (CDK13) in cardiogenesis and CHD was studied using a transgenic mouse model (Cdk13tm1b) carrying deletion of exons 3 and 4, causing loss of function.
Qazi Waheed‐Ullah, Anna Wilsdon, Aseel Abbad, Sophie Rochette, Frances Bu'Lock, Asma Ali Saed, Marc‐Phillip Hitz, J. David Brook, Siobhan Loughna   +8 more
wiley   +1 more source

Abnormal Haemodynamic Flow Patterns in Bicuspid Pulmonary Valve Disease

Frontiers in Physiology, 2017
Abnormal flow patterns in the aortas of those with bicuspid aortic valves (BAVs) are increasingly recognized as important in the pathogenesis of aortic dilatation but pulmonary flow patterns in bicuspid pulmonary valves have not been studied.
Malenka M. Bissell, Margaret Loudon, Stefan Neubauer, Saul G. Myerson   +3 more
doaj   +1 more source

The Evolving Landscape of CHD Genetics: A Contemporary Guide to Genetic Testing and Management

Journal of Paediatrics and Child Health, EarlyView.
ABSTRACT Congenital heart disease (CHD) is the most common birth defect, affecting an estimated 9.4/1000 infants globally. The genetics of CHD is complex, with most cases thought to have multifactorial aetiology, implicating both genetic and environmental factors.
Bridget R. O'Malley, Gary F. Sholler, Janine Smith, Gillian M. Blue   +3 more
wiley   +1 more source