Results 171 to 180 of about 1,260,054 (243)

ATL2 Recruits TRAK1 to Promote Mitochondrial Transport at ER–Mitochondria Contact Sites

open access: yesAdvanced Science, EarlyView.
ABSTRACT Mitochondrial transport and distribution are crucial for cellular homeostasis, yet whether and how they are regulated by endoplasmic reticulum (ER)–mitochondria contact sites remains unclear. Here, we demonstrate that the ER protein atlastin‐2 (ATL2) orchestrates mitochondrial transport and distribution by promoting assembly of the transport ...
Yiru Cheng   +9 more
wiley   +1 more source

Dicationic Ion‐Pair Doping Enables Stable and High‐Performing Conducting Polymers for Organic Thermoelectrics

open access: yesAdvanced Science, EarlyView.
TAB–2TFSI enables efficient ion‐pair doping across a wide range of conjugated polymers, where the strongly oxidizing TAB core drives charge transfer, and the TFSI counterions promote favorable ionic compensation. This dicationic dopant promotes uniform dopant distribution, improves structural order, and increases carrier delocalization, establishing a ...
Juhyung Park   +14 more
wiley   +1 more source

RNA Promotes Synapsin Condensates That Organize Synaptic Vesicles in Live Neurons and Enable Localized Translation in Reconstituted System

open access: yesAdvanced Science, EarlyView.
Condensates at synapses organize synaptic vesicles (SVs) and are crucial for efficient neurotransmitter release, yet how RNA contributes to this mesoscale architecture remains poorly understood. Here we uncover that RNA modulates synapsin–driven condensates.
Branislava Rankovic   +21 more
wiley   +1 more source

Computationally Evidence‐Grounded Sequence‐First Design of Peptide Binders

open access: yesAdvanced Science, EarlyView.
BOND‐PEP enables controllable, sequence‐first peptide binder design by grounding generation in binding evidence retrieved for each target. It uses topology‐conditioned message passing to integrate relevant peptide examples with the target protein sequence, forming a residue‐level representation that guides the generation of diverse, target‐specific ...
Wenze Ding
wiley   +1 more source

Perceived Time Shapes Physical Fatigue Accumulation and Its Neural Oscillatory Correlates

open access: yesAdvanced Science, EarlyView.
Can a clock change the course of physical fatigue? By covertly manipulating the clock calibration during repeated isometric contractions, we showed that perceived time shapes fatigue accumulation and frontal oscillatory dynamics. While fatigue accumulation was only reduced when the clock was slowed down, frontal oscillatory dynamics followed perceived ...
Pierre‐Marie Matta   +3 more
wiley   +1 more source

Asymmetric Evolution of Antennal Cell Types Underlies a Derived Ammonia‐Sensing Logic for Ecological Adaptation in Bactrocera dorsalis

open access: yesAdvanced Science, EarlyView.
Comparative antennal single‐nucleus transcriptomics reveals cell‐type‐dependent transcriptomic divergence in Bactrocera dorsalis, with similar structural cells but divergent sensory neurons. This neuronal diversification is associated with a distinct ammonia‐sensing pathway, linking female attraction to bird‐dropping‐associated cues with nutritional ...
Wei Liu   +7 more
wiley   +1 more source

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