Clinical Impact of NOTCH3 Variant Location After First Stroke in CADASIL
ABSTRACT Objective Despite its monogenic origin, Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy exhibits marked variability in clinical expression and severity. Variants in the NOTCH3 gene, within epidermal growth factor‐like repeat domains 1–6 or 7–34, are known to influence disease onset, but their impact ...
Léa Aguilhon +5 more
wiley +1 more source
Adjunctive xanomeline/trospium in clozapine-resistant schizophrenia: two case reports demonstrating limited response. [PDF]
Dang VM, Powers JM, Markota M, Leung JG.
europepmc +1 more source
ABSTRACT Objective To clarify the clinical relevance of dopamine transporter single‐photon emission computed tomography (DAT‐SPECT) abnormalities in amyotrophic lateral sclerosis (ALS), with a prespecified focus on sex‐stratified associations with disease progression and short‐term prognosis.
Tomoya Kawazoe +7 more
wiley +1 more source
Assessing the Impact of Social and Psychological Factors on Consumers' Willingness to Pay for Low-Carbon Beef: Evidence from Urban China. [PDF]
Li J, Lin Y, Bai X.
europepmc +1 more source
Objective This study assessed sarilumab in treating patients with polyarticular‐course juvenile idiopathic arthritis (pcJIA). Methods This phase 2b, open‐label study (NCT02776735) consisted of three sequential parts (each with a core‐treatment and extension phase).
Fabrizio De Benedetti +19 more
wiley +1 more source
The price of safety and convenience: Urban shoppers' willingness to pay for hygienic market stalls and minimal processing of leafy vegetables in Kenya. [PDF]
Mwambi M +5 more
europepmc +1 more source
Objective We aimed to validate the Pediatric Arthritis Ultrasound Scoring System (PAUSS) for upper extremity joints in children with juvenile idiopathic arthritis (JIA). Methods Children with JIA were evaluated for elbow, wrist, or finger arthritis by clinical examination (CE) and musculoskeletal ultrasound (MSUS) with images scored according to the ...
Patricia Vega‐Fernandez +12 more
wiley +1 more source
Multi-Party Semi-Quantum Simultaneous Ascending Auction Protocol Based on Single-Particle States. [PDF]
Wu X, Yang Y, Wang B, Zhang Y, Han Y.
europepmc +1 more source
Sex Differences in Medication Discontinuation in Axial Spondyloarthritis
Objective We examined sex differences in medication discontinuation among patients with axial spondyloarthritis (axSpA) initiating tumor necrosis factor inhibitors (TNFi), interleukin‐17 inhibitors (IL‐17i), or JAK inhibitors (JAKi). Methods Using data from the Rheumatology Informatics System for Effectiveness (RISE) Registry (2003–2025), we assessed ...
Rachael Stovall +9 more
wiley +1 more source
Availability and Affordability of Essential Antihypertensive Medicines in Public and Private Primary Care Drug Facilities in a 4<sup>th</sup> Class Municipality in the Philippines. [PDF]
Lat RMM, Samonte RJN, Ngo FLU.
europepmc +1 more source

