Results 41 to 50 of about 241,539 (269)

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

Multiplicative Bidding in Online Advertising [PDF]

open access: yes, 2014
In this paper, we initiate the study of the multiplicative bidding language adopted by major Internet search companies. In multiplicative bidding, the effective bid on a particular search auction is the product of a base bid and bid adjustments that are ...
Bateni, MohammadHossein   +3 more
core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Optimisation of processes of logistics companies in tender placement of orders

open access: yesВестник университета
The article considers the problem of the occurrence of implicit costs for logistics companies during the tender placement of orders using the example of courier services.
E. L. Tcai
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

The longer term refinancing operations of the ECB [PDF]

open access: yes, 2004
This paper employs individual bidding data to analyze the empirical performance of the longer term refinancing operations (LTROs) of the European Central Bank (ECB). We investigate how banks’ bidding behavior is related to a series of exogenous variables
Bindseil, Ulrich   +2 more
core  

Real-Time Bidding by Reinforcement Learning in Display Advertising [PDF]

open access: yes, 2017
The majority of online display ads are served through real-time bidding (RTB) --- each ad display impression is auctioned off in real-time when it is just being generated from a user visit.
Cai, Han   +6 more
core   +2 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Competitive bidding with a bid floor [PDF]

open access: yesInternational Journal of Economic Theory, 2011
We study competitive bidding with an explicit bid floor, motivated by minimum wage legislation and minimum labor standards. We derive the equilibrium strategies in, and compare the expected procurement costs among, the first-price, second-price, English, and Dutch auctions in a private-cost model.
Chen, BR, Chiu, YS
openaire   +4 more sources

Two Tier Slicing Resource Allocation Algorithm Based on Deep Reinforcement Learning and Joint Bidding in Wireless Access Networks

open access: yesSensors, 2022
Network slicing (NS) is an emerging technology in recent years, which enables network operators to slice network resources (e.g., bandwidth, power, spectrum, etc.) in different types of slices, so that it can adapt to different application scenarios of 5
Geng Chen   +3 more
doaj   +1 more source

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