Results 61 to 70 of about 241,539 (269)
Targeting p38α in cancer: challenges, opportunities, and emerging strategies
Molecular Oncology, EarlyView.p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source
MODEL STRATEGI PENAWARAN UNTUK PROYEK KONSTRUKSI DI INDONESIA
Civil Engineering Dimension, 1999 This research is a study on certain bidding strategy models, based on the maximum expected profit, as often used in developed countries. The models chosen for this research are: the Friedman model, the Gates model and the Ackoff & Sasieni model ...
Harry Patmadjaja
doaj
, 2005 Online auctions are fast gaining popularity in today's electronic commerce. Relative to offline auctions, there is a greater degree of multiple bidding and late bidding in online auctions, an empirical finding by some recent research. These two behaviors
Boatwright, Peter +2 more
core +2 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Effects of a rationing rule on the ausubel auction: a genetic algorithm implementation [PDF]
, 2007 The increasing use of auctions as a selling mechanism has led to a growing interest in the subject. Thus both auction theory and experimental examinations of these theories are being developed.
Isasi, Pedro +3 more
core +3 more sources
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
BuildingsThere have been limited empirical studies that aimed to establish the tenability of the stationarity assumption in recurrent construction bidding, and thus the need for and importance of allowing for continuity in bidding models remain unexplored.
Yixi Zhang +3 more
doaj +1 more source
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
Integration of experience feedback into the product lifecycle: an approach to best respond to the bidding process [PDF]
, 2012 Bidding process allows a client to choose a bidder to realize an embodiment of work, supply or service. From the bidder point of view, there are several obvious risks when responding because he bets on a future development that hasn’t been yet realized ...
Botero Lopez, Juan Diego +3 more
core +1 more source
Labour Economics, 2018 Abstract We develop a simple competing job auction model to study wages and employment within teams. If synergies favor larger teams, the basic competing job auction model predicts that workers are generally paid a wage less than their marginal product of labor and that there is too much entry of firms. We then extend the model to allow for workplace
Julien, B, Kennes, J, Ritter, M
openaire +3 more sources