Results 31 to 40 of about 3,899 (265)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Fully soft switched high step‐up/down bidirectional buck/boost converter with reduced switch voltage stress

IET Power Electronics, 2023
A fully soft switched high step‐up/down bidirectional converter is presented in this paper. The high voltage conversion ratio is achieved by a pair of coupled inductors along with a switched capacitor while all active switches operate at zero voltage ...
Mohsen Packnezhad, Pouria Talebi, Hosein Farzanehfard   +2 more
doaj   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Research on the Bidirectional Converter Setting Scheme for Urban Rail Transit Traction Power Supply System

Chengshi guidao jiaotong yanjiu
ObjectiveBidirectional converter technology is an important direction in the application technology research of intelligent and green urban rail transit traction power supply. Due to the differences in external characteristics of bidirectio-nal converter
Lijun DAI, Lixin YANG, Yu ZHANG, Yilong CHEN, Yifei WANG, Minghua CHENG   +5 more
doaj   +1 more source

Modeling and Design of Split-Pi Converter

Energies, 2022
High-power bidirectional dc–dc converters are being widely employed in renewable energy interfacing, energy storage, electric vehicle charging, military, aerospace, and marine applications.
Geethanjali Subramaniyan, Vijayakumar Krishnasamy, Jagabar Sathik Mohammed   +2 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Magnetically Coupled Buck–Boost Bidirectional DC–DC Converter

IEEE Transactions on Industrial Electronics, 2021
A new nonisolated bidirectional dc–dc converter with noninverting output and buck–boost operation is proposed and described in this article. The passive components arrangement in the proposed magnetically coupled buck–boost bidirectional dc–dc (MCB 3 ) converter makes it possible to use triple-phase shift (TPS) modulation, originally intended for the ...
Alba Rodriguez-Lorente, Andres Barrado, Carlos Calderon, Antonio Lazaro, Pablo Zumel   +4 more
openaire   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Wide Voltage Gain Range Bidirectional DC-DC Converter with Reduced Switches Count and Buck-Boost Characteristic in Both Power Flow Directions

Energies
Several applications require bidirectional power converters with high-voltage gain. While several topologies have been proposed, none of them exhibit Buck-Boost characteristics in both forward and reverse power transfer.
Victor Fernão Pires, Armando Cordeiro, Daniel Foito, Tito Amaral, José Fernando Silva   +4 more
doaj   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source