Results 101 to 110 of about 176,178 (304)

Unlocking the Potential of MXene‐Based Electrochemical Biosensors: A Review of Biofunctionalization Strategies and Biosensing Principles

Advanced Materials Technologies, EarlyView.
ABSTRACT Electrochemical biosensors enable the accurate and timely detection of clinical biomarkers, improving healthcare and precision medicine. MXene nanosheets, a class of 2D transition metal carbides, nitrides, and carbonitrides, are promising materials for developing next‐generation electrochemical biosensors due to their unique physicochemical ...
Muhsin Ali, Sharat Chandra Barman, Isobel Steer, Aya H. Alshareef, Dana Alsulaiman   +4 more
wiley   +1 more source

A Bifunctional T3SS‐Effector Simultaneously Cleaves Host MAP Kinase and Inhibits PPM1A Phosphatase

Advanced Science, EarlyView.
Pathogenic bacteria exploit the metalloprotease effector NleD to subvert host defenses. Structural, biochemical, and infection analyses reveal a bifunctional mechanism by which NleD binds and inhibits the host phosphatase PPM1A while preserving its proteolytic activity against MAPKs.
Yaakov Socol, Lihi Gur‐Arie, Netanel Tzarum, Tamara Wellins, Naama Katsowich, Miriam Ravins, Michal Bejerano‐Sagie, Klil Cohen, Oded Livnah, Joshua N. Adkins, Ernesto Nakayasu, Alexei Savchenko, Yeu Khai Choong, Nikhil Kumar Tulsian, Saturo Machida, Sigal Ben‐Yehuda, Yael Litvak, J. Sivaraman, Ilan Rosenshine   +18 more
wiley   +1 more source

RNF213 Is an Interferon‐Stimulated Gene That Targets Influenza A Virus NP and Activates MDA5 to Restrict Infection

Advanced Science, EarlyView.
RNF213 is characterized as a dual‐functional antiviral effector. It directly mediates the degradation of the influenza A virus nucleoprotein (NP) while simultaneously activating the MDA5‐mediated innate immune signaling pathway. This coordinated response establishes a powerful host defense system against viral infection. ABSTRACT Influenza A virus (IAV)
Haoning Li, Yuying Zhang, Jingjing Wang, Qianqian Zhang, Hailiang Sun, Fanhua Wei   +5 more
wiley   +1 more source

MOx/Rh Metallene with Energetic Interfaces as Efficient Bifunctional Electrocatalyst for Durable Water Splitting

Advanced Science, EarlyView.
 . ABSTRACT Developing excellent activity and stability bifunctional electrocatalysts for alkaline water splitting remains challenging. This work constructs ultrathin MOx/Rh metallene heterostructures (M = Fe, Co, Ni) via atmosphere‐controlled solvothermal synthesis, achieving uniform MOx nanoclusters on Rh metallene with optimized interfaces. The FeOx/
Ruilong Wei, Yuner Lin, Shanshan Ye, Shuo Wang, Jing Gao, Chaochao Tao, Shengqian Wang, Pei Xiong, Hang Zhang, Hualan Xu, Shengliang Zhong   +10 more
wiley   +1 more source

Syntheses, characterization, luminescent and magnetic properties of polymer bifunctional fibers containing terbium complexes and Fe3O4 nanoparticles

Materials Research Express
The combination of electrospun nanofibers and nanoparticles is opening up potential in the field of bifunctional materials. Herein, polystyrene (PS, Mw ≈ 260, 000), polyvinyl pyrrolidone (PVP, Mw ≈1, 300, 000), and poly(methyl methacrylate) (PMMA, Mw ...
Lina Liu, Kexin Wang, Xiuyun An, Yujun Wang, Feng Shan, Jia Liu, Chunjuan Tang, Jianfeng Su, Ruifei Qin   +8 more
doaj   +1 more source

Synthesis of ZnS:Mn–Fe3O4 bifunctional nanoparticles by inverse microemulsion method

Journal of Science: Advanced Materials and Devices, 2016
ZnS:Mn–Fe3O4 bifunctional nanoparticles were synthesized by inverse microemulsion method for biomedicine applications. The bifunctional nanoparticles were combined from prepared ZnS:Mn and Fe3O4 nanoparticles in a SiO2 cover matrix.
Chu Tien Dung, Luu Manh Quynh, Nguyen Phuong Linh, Nguyen Hoang Nam, Nguyen Hoang Luong   +4 more
doaj   +1 more source

Understanding and Overcoming Antibody‐Drug Conjugate Resistance: Biological Mechanisms and Emerging Analytical Frameworks in Breast Cancer

Advanced Science, EarlyView.
Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley   +1 more source

Cryo‐EM Structure Guided Engineering of Botulinum Neurotoxin A With Advanced Receptor Binding Affinity and Therapeutical Benefits

Advanced Science, EarlyView.
The butterfly unfolded wing in an open form structure of botulinum neurotoxin type A (BoNT/A) at physiological‐state was confirmed at 2.85 Å resolution by cryo‐electron microscopy (cryo‐EM). Structure‐guided protein engineering significantly enhanced the receptor‐binding affinity, therapeutic efficacy, and safety of the engineered toxin variants ...
Wenrui Wang, Zhaxi Zerang, Linjin You, Ziye Liu, Rong Nie, Fuwei Qi, Fenfen Gao, Chengmu Zhao, Wantong Ma, Jinghan He, Xiaoru Wang, Shanquan Wu, Bo Liu, Xinyao Liu, Dongsheng Lei, Dejuan Zhi, Dongsheng Wang   +16 more
wiley   +1 more source

Partial Exsolution Enables Superior Bifunctionality of Ir@SrIrO3 for Acidic Overall Water Splitting

Advanced Science
The pursuit of efficient and durable bifunctional electrocatalysts for overall water splitting in acidic media is highly desirable, albeit challenging.
Ling Zhao, Zetian Tao, Maosheng You, Huangwei Xiao, Sijiao Wang, Wenjia Ma, Yonglong Huang, Beibei He, Qi Chen   +8 more
doaj   +1 more source

Electrochemically Enhanced Photocatalytic Degradation of Organic Pollutant on p-PbO2-TNT/Ti/TNT Bifuctional Electrode

International Journal of Electrochemical Science, 2012
A bifunctional PbO2-TNT/Ti/TNT electrode with both photo- and electro-catalytic performance was prepared. Firstly, TiO2 nanotube (TNT) electrode was fabricated on the Ti foils by anodic oxidation and then deposited with β-PbO2 on the reverse side of TNT ...
Yanming Shen, Fei Li, Shifeng Li, Dongbin Liu, Lihui Fan, Yi Zhang   +5 more
doaj   +1 more source