Results 41 to 50 of about 113,681 (310)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Bifunctional scaffolds for tumor therapy and bone regeneration: Synergistic effect and interplay between therapeutic agents and scaffold materials

Materials Today Bio, 2022
Bone tumor patients often face the problems with cancer cell residues and bone defects after the operation. Therefore, researchers have developed many bifunctional scaffolds with both tumor treatment and bone repair functions.
Jiongpeng Yuan, Zhaoyi Ye, Yaoxun Zeng, Zhenxing Pan, ZhenZhen Feng, Ying Bao, Yushan Li, Xujie Liu, Yan He, Qingling Feng   +9 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

A bifunctional endolytic alginate lyase with two different lyase catalytic domains from Vibrio sp. H204

Frontiers in Microbiology
Alginate lyases can fully degrade alginate into various size-defined unsaturated oligosaccharide products by β-elimination. Here, we identified the bifunctional endolytic alginate lyase Aly35 from the marine bacterium Vibrio sp. Strain H204.
Chune Peng, Qingbin Wang, Qingbin Wang, Wei Xu, Xinkun Wang, Qianqian Zheng, Xiaohui Liang, Xiaodan Dong, Fuchuan Li, Lizeng Peng   +9 more
doaj   +1 more source

Kinetics and mechanism of N-chlorosaccharin oxidation of malic acid

Orbital: The Electronic Journal of Chemistry, 2010
Kinetic study of N-chlorosaccharin (NCSA) oxidation of malic acid (MA) in aqueous acetic acid medium in presence of perchloric acid has been investigated.
Sanjay Kumar Singh, Hari D. Gupta, Mohammad U. Khan, Santosh S. Baghel   +3 more
doaj   +1 more source

An Efficient Symmetric Electrolyzer Based On Bifunctional Perovskite Catalyst for Ammonia Electrolysis

Advanced Science, 2021
Ammonia is a natural pollutant in wastewater and removal technique such as ammonia electro‐oxidation is of paramount importance. The development of highly efficient and low‐costing electrocatalysts for the ammonia oxidation reaction (AOR) and hydrogen ...
Mengfei Zhang, Hao Li, Xiuyun Duan, Peimiao Zou, Georgina Jeerh, Boyao Sun, Shigang Chen, John Humphreys, Marc Walker, Kui Xie, Shanwen Tao   +10 more
doaj   +1 more source

Effect of Preparation Process of La0.95FeO3-δ/C Composite Electrode on Preparation and Bifunctional Electrocatalytic Properties

Shanghai Jiaotong Daxue xuebao, 2021
In order to optimize the bifunctional electrocatalytic performance of La0.95FeO3-δ, the effects and influencing mechanism of carbon morphology, electrode ink preparation, and catalyst loading on the bifunctional electrocatalytic performance of ...
HU Huanming, YANG Fan, ZHANG Junliang
doaj   +1 more source

Molecular Glues & Bifunctional Compounds: Therapeutic Modalities Based on Induced Proximity [PDF]

This Perspective explores molecular glues and bifunctional compounds – proximity-inducing compounds – and offers a framework to understand and exploit their similarity to hot spots, missense mutations, and posttranslational modifications (PTMs)
Stuart, Schreiber
core   +1 more source

Enhancement of the Through‐Thickness Electrical Conductivity of Carbon‐Fiber‐Reinforced Plastics Using Large Graphite Particles

Advanced Engineering Materials, EarlyView.
To enhance through‐thickness conductivity without sacrificing impregnation, large spherical graphite particles are intentionally employed in a low‐viscosity resin. Unlike finer conductive fillers, these particles remain outside the fiber bundles and accumulate in resin‐rich interlaminar regions during molding.
Keito Hosoe, Yu Zhou, Shintaro Kamiyama, Takao Okada, Tomohiro Yokozeki, Ryoma Tokonami, Tatsuhiro Takahashi   +6 more
wiley   +1 more source

Utilização de iniciadores multifuncionais na polimerização do estireno em suspensão [PDF]

, 2004
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Engenharia QuímicaOs estudos a cerca de todos os aspectos que envolvem materiais termoplásticos tem recebido uma singular atenção a partir ...
Arioli, Rafael
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