Results 151 to 160 of about 306,986 (339)

RUNX1/SLAMF3 Axis Drives Immunosuppression to Contribute to Colorectal Cancer Liver Metastasis by Blocking Phagocytosis and Depleting C1QC+ Tumor‐Associated Macrophages

open access: yesAdvanced Science, EarlyView.
This study identifies the RUNX1/SLAMF3 axis as a key driver of colorectal cancer liver metastasis (CRLM). SLAMF3 suppresses macrophage phagocytosis and depletes C1QC⁺ tumor‐associated macrophages, promoting an immunosuppressive microenvironment. Targeting this axis restores macrophage and CD8⁺ T cell activity and reduces metastasis.
Yinheng Luo   +10 more
wiley   +1 more source

CO2‐DBU‐Triggered Photoredox‐Catalyzed Direct α‐C‐H Alkylation of Alcohols

open access: yesAdvanced Science, EarlyView.
An efficient photoinduced and metal‐free method is developed for direct α‐C–H monoalkylation of alcohols utilizing the CO2‐DBU system as the hydrogen bond acceptor (HBA) in the presence of H2O, allowing for selective functionalization of alcohols with a broad substrate scope.
Zeyu Zhang   +5 more
wiley   +1 more source

Spatiotemporal Transcriptomic Atlas Reveals the Regulatory Mechanisms Underlying Early Inflorescence Development and Sex Differentiation in Spinach

open access: yesAdvanced Science, EarlyView.
High‐resolution spatiotemporal transcriptomic data from male and female spinach inflorescences across four key stages first reveal the sex differentiation initiates at the four‐leaf stage and is governed by epigenetic regulation via the SpMSI1‐SpHDT2 complex.
Chen You   +10 more
wiley   +1 more source

FOXM1 Protects Against Myocardial Ischemia‐Reperfusion Injury in Rodent and Porcine Models by Suppressing MKRN1‐Dependent LKB1 Ubiquitination

open access: yesAdvanced Science, EarlyView.
FOXM1 maintains mitochondrial bioenergetic function by inhibiting MKRN1‐mediated ubiquitination of LKB1 in cardiomyocytes. Loss of FOXM1 in cardiomyocytes results in upregulation of MKRN1, which enhances LKB1 ubiquitination and disrupts AMPK signaling and energy metabolism pathways. Conversely, FOXM1 overexpression preserves mitochondrial bioenergetics
Shuai Song   +17 more
wiley   +1 more source

A kinematically Bifurcated Metamaterial for Integrated Logic Operation and Computing

open access: yesAdvanced Science, EarlyView.
A family of 2n‐side kinematic polygonal modules with n decoupled inputs and 2n extreme configurations via kinematic bifurcation is proposed. It allows integrating seven basic logic gates on a quadrilateral module. Moreover, a minimized Parallel Computing Sum of Products function is developed, enabling all 2‐bit arithmetic (including division ...
Kaili Xi   +6 more
wiley   +1 more source

Bifurcation from simple eigenvalues

open access: yes, 1971
M. Crandall, P. Rabinowitz
semanticscholar   +1 more source

Durable Lithium Metal Anodes Enabled by {110}‐Textured Epitaxy on a LiF@Ag Commensurate Heterostructure

open access: yesAdvanced Science, EarlyView.
Utilizing their commensurate lattices, a LiF@Ag heterostructure is fabricated for Li epitaxy, featuring Ag nanoparticles grown on 2D LiF layers. The composition pinning effect inhibits Li‐Ag alloying and maintains the high lithiophilicity and fast adatom migration associated with Ag.
Liming Zhang   +7 more
wiley   +1 more source

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