Results 91 to 100 of about 23,444,297 (308)

Bifurcation and stability analysis of aircraft turning manoeuvres [PDF]

, 2008
During ground manoeuvres a loss of lateral stability due to the saturation of the main landing gear tyres can cause the aircraft to enter a skid or a spin. The lateral stability is governed not only by aspects of the gear design, such as its geometry and
Coetzee, EB, Rankin, AJ, Lowenberg, MH, Krauskopf, B   +3 more
core  

A Biofabricated Human Acinus‐on‐a‐Chip Unveils Mechanotransductive Drivers of Ventilator‐Induced Lung Injury via Decoupling Volutrauma and Barotrauma

Advanced Science, EarlyView.
This bioinspired acinus‐on‐a‐chip recapitulates VILI pathology, revealing that volutrauma drives P53/NF‐κB pathways while barotrauma triggers mitochondrial‐Wnt dysregulation. A fibrotic transitional cell cluster was identified. Pharmacological interventions targeting these pathways significantly ameliorated injury, establishing a mechanobiological ...
Heng Lu, Liansheng Liu, Zengyong Hu, Shuxian Fang, Ruohan Ren, Sidi Liu, Meng Zhao, Zhiting Luo, Ziyue Zhang, Wenlong Shao, Qian Liu   +10 more
wiley   +1 more source

Loop Modeling of the Reciprocal Inhibition Between HPA and HPG Endocrine Axes Reveals Transitions to Bistability and Critical Bifurcation Parameters

Applied Sciences
Endocrine axes are pathways of interactions involved in various aspects of the organism’s functioning, also implicated in deviations from physiological states leading to pathological conditions.
Ilaria Demori, Seth Siriya, Bruno Burlando   +2 more
doaj   +1 more source

Bifurcation Analysis of a Certain Hodgkin-Huxley Model Depending on Multiple Bifurcation Parameters

Mathematics, 2018
In this paper, we study the dynamics of a certain Hodgkin-Huxley model describing the action potential (AP) of a cardiac muscle cell for a better understanding of the occurrence of a special type of cardiac arrhythmia, the so-called early ...
André H. Erhardt
doaj   +1 more source

Phase Separation of TRIM21 Modulates PTPN14 Stability to Drive Flow‐Dependent Endothelial Activation and Atherogenesis

Advanced Science, EarlyView.
Disturbed flow promotes the formation of TRIM21‐rich biomolecular droplets, which concentrate TRIM21 and PTPN14 and facilitate their SPRY‐FERM interaction (illustrated by the TRIM21 D355‐PTPN14 R132 salt bridge). This condensate‐driven proximity enables TRIM21 to catalyze K48‐linked polyubiquitination of PTPN14 at lysine 956, leading to proteasome ...
Xue He, Qiannan Ma, Xue Wang, Jiaxu Mang, Chufeng Li, Bingjun Wu, Liu Yao, Yequn Chen, Qiankun Bao, Yi Zhu, Jinlong He   +10 more
wiley   +1 more source

Lie Symmetry, Conservation Laws, and Dynamical Analysis of Ionic Currents in the Microtubule Model

Mathematics
In this article, we investigate the dynamical analysis and soliton solutions of the microtubule equation. First, the Lie symmetry method is applied to the considered model to reduce the governing partial differential equation into an ordinary ...
Beenish, Abdulaziz Khalid Alsharidi
doaj   +1 more source

A new chaotic hyperjerk system with four quadratic nonlinearities, its bifurcation analysis, multistability, circuit design and complete synchronization design via active backstepping control [PDF]

Archives of Control Sciences
In this research work, we propose a new four-dimensional chaotic hyperjerk system with four quadratic nonlinearities. We carry out a detailed bifurcation analysis and derive conditions for the existence of a Hopf bifurcation for the new hyperjerk system.
Sundarapandian Vaidyanathan, Aceng Sambas, Irene M. Moroz, Chittineni Aruna, Mohamad Afendee Mohamed, Arun Sundaram   +5 more
doaj   +1 more source

Uncoupling Type I Interferon Benefits From Inflammatory Toxicity: Transformer‐Prioritized Precision Agonists for Potent and Safer Cancer Immunotherapy

Advanced Science, EarlyView.
A Transformer‐based AI framework, DLINP, screens millions of compounds to identify Co68, a cobalt‐pincer organometallic complex that biases TLR4‐MD2 signaling toward antitumor interferon activation while suppressing inflammatory toxicity through an early TLR4‐SYK‐STAT1 axis.
Xuefei Guo, Yang Zhao, Xianle Rong, Xingyu Chen, Xiao Wang, Tianyi Liu, Yunfei Xie, Yushu Zou, Pingsen Zhao, Qiang Liu, Fuping You   +10 more
wiley   +1 more source

Non-Robust Dynamic Inferences from Macroeconometric Models: Bifurcation Stratification of Confidence Regions [PDF]

Grandmont (1985) found that the parameter space of the most classical dynamic models are stratified into an infinite number of subsets supporting an infinite number of different kinds of dynamics, from monotonic stability at one extreme to chaos at the ...
Barnett, William A., Duzhak, Evgeniya A.
core   +2 more sources

Matrix Stiffness Orchestrates Mesenchymal Stem Cell Lineage Commitment Toward Osteogenesis and Adipogenesis Through the PIEZO1/SP1/STC2 Axis

Advanced Science, EarlyView.
Matrix stiffness directs mesenchymal stem cell lineage commitment through PIEZO1‐dependent activation of the SP1/STC2 pathway. Stiff matrices favor osteogenesis and suppress adipogenesis, whereas the loss of PIEZO1 function impairs early bone formation. STC2 retains lineage‐regulatory activity even when PIEZO1 is inactive.
Shuo Zhang, Siteng Li, Wenzhong Chen, Qingcheng Song, Haiyue Zhao, Peng Wang, Yiran Zhang, Wenquan Liang, Shaowei Zheng, Juan Wang, Wei Chen, Yanbin Zhu, Yingze Zhang   +12 more
wiley   +1 more source