Results 121 to 130 of about 73,924 (320)
Advanced Science, EarlyView.SETDB2 epigenetically represses Smad3 transcription by increasing H3K9me3 enrichment at its promoter, thereby mitigating podocyte dysfunction in DKD. The transcription factor TCF21 binds directly to the Setdb2 promoter and enhances its expression in podocytes. Abstract Podocyte dysfunction represents both an early pathological hallmark and a key driver
Lanfang Li +14 more
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Chaos and Control in Coronary Artery System
Discrete Dynamics in Nature and Society, 2012 Two types of coronary artery system N-type and S-type, are investigated. The threshold conditions for the occurrence of Smale horseshoe chaos are obtained by using Melnikov method.
Yanxiang Shi
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Comparative Single‐Cell Transcriptomic Atlas Reveals the Genetic Regulation of Reproductive Traits
Advanced Science, EarlyView.A cross‐species single‐cell transcriptomic atlas of reproductive and central nervous system tissues from sheep and humans reveals conserved cellular programs and regulatory networks that regulated fertility. Integration with GWAS for sheep lifetime average litter size identifies UNC5–SLIT–BMP signaling as a core pathway coordinating neuroendocrine ...
Bingru Zhao +8 more
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Advanced Science, EarlyView.Microglial AXL drives white matter repair after stroke by orchestrating the cleanup of myelin debris. Mechanistically, AXL signals through EGR1 to boost Smpd1 transcription, regulating sphingolipid metabolism and preventing lipid droplet toxicity. Restoring the pathway with ASM therapy mitigates damage, positioning AXL as a key node for therapeutic ...
Junqiu Jia +13 more
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Acomplete classification of bifurcation diagrams of classes of multiparameter p ‐Laplacian boundary value problems [PDF]
, 2007 Kuo‐Chih Hung, Shin–Hwa Wang
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Advanced Science, EarlyView.This study repurposes mitochondrial DNA mutations as endogenous barcodes for lineage tracing in human pluripotent stem cell‐derived organoids. Integrated with transcriptomic and spatial data, it reveals NOTCH‐mediated stromal‐progenitor crosstalk orchestrates clonal dynamics and spatial zonation during early hematopoietic development, offering a non ...
Yan Xue +17 more
wiley +1 more source
Advanced Science, EarlyView.This study shows that amyloid fibrils form nematic condensates via liquid–liquid crystalline phase separation (LLCPS). With increasing pH, this transition shifts toward disordered condensates formed through liquid–liquid phase separation (LLPS), in which birefringence with lack of a coherent nematic field symmetry originates from enthalpic fibril ...
Milad Radiom, Raffaele Mezzenga
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Jixie chuandongThe quality of the cut end surface of pipelines is one of the important factors to ensure the safe operation of the pipeline system. However, the existence of nonlinear factors in the pipeline cutting process may lead to chaos, quasi-periodic and other ...
Zhao Jiayi +5 more
doaj
Bifurcation diagram in case of ring interferometer containing liquid crystal: effect of diffusion [PDF]
, 1998 Anton Magazinnikov +1 more
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Bifurcation diagrams for singularly perturbed system
Electronic Journal of Qualitative Theory of Differential Equations, 2012 Summary: We consider a singularly perturbed system where the fast dynamics of the unperturbed problem exhibits a trajectory homoclinic to a critical point. We assume that the slow time system is \(1\)-dimensional and it admits a unique critical point, which undergoes to a bifurcation as a second parameter varies: transcritical, saddle-node, or ...
openaire +2 more sources