Results 71 to 80 of about 15,425 (247)

Intelligent Soft Opto‐Magnetic Robot for Minimally Invasive Interventional Therapy

Advanced Science, EarlyView.
An intelligent soft opto‐magnetic (iSOM) robot is developed that integrates remote magnetic actuation, skin‐mimic tactile perception, and photothermal ablation in a near‐millimeter‐scale design. It enables precise intraluminal navigation and localized ablation while providing real‐time optical feedback to support safe and accurate minimally invasive ...
Jingjing Guo, Xiaoyan Guo, Jian Wei, Miaowen Jiang, Qifa Su, Xian Xia, Zhuozhou Li, Rong Cai, Jianguo Ma, Bo Fu, Ming Li, Jing Zhong, Lijun Xu, Xunming Ji   +13 more
wiley   +1 more source

Dual Aptamers‐Based SETDB1 PROTACs as Effective Anti‐Tumor Strategies for Breast Cancer

Advanced Science, EarlyView.
This study establishes dual‐aptamer PROTACs targeting SETDB1 using a SETDB1‐specific aptamer conjugated to AS1411. The designed PROTACs penetrate cells, recruit MDM2 to degrade SETDB1, and inhibit cancer cell proliferation and migration. Remarkably, they also overcome tamoxifen resistance and enhance CD8+ T cell cytotoxicity, suppressing tumor growth ...
Yanxuan Guo, Yingge Lv, Shuyu Huang, Chang Liu, Yan Ouyang, Bei Lan, Chenghao Xuan   +6 more
wiley   +1 more source

Nonsmooth Vibration Characteristic of Gear Pair System with Periodic Stiffness and Backlash

Discrete Dynamics in Nature and Society, 2018
As the most widely used power transmission device in mechanical equipment, the vibration characteristics of gears have a very important influence on the working performance.
Minjia He, Shuo Li, Zhenjun Lin, Jinjin Wang, Shuang Liu, Ruolan Hao   +5 more
doaj   +1 more source

Systematic Metabolic Engineering and Model‐Guided Optimization for High‐Level Production of L‐Theanine from Xylose in Escherichia coli

Advanced Science, EarlyView.
This study is pioneering in constructing the shortest known synthetic pathway for L‐theanine production from xylose within E coli. Through comprehensive metabolic engineering strategies, our engineered strain achieved the highest reported L‐theanine titer from xylose, with a titer of 95.42 g/L, and a yield of 0.55 g/g.
Haolin Han, Boyuan Xue, Guangqi Shan, Meng Meng, Shaojie Wang, Haijia Su   +5 more
wiley   +1 more source

Accelerating Catalyst Materials Discovery With Large Artificial Intelligence Models

Angewandte Chemie, EarlyView.
AI‐empowered catalysis research via integrated database platform, universal machine learning interatomic potentials (MLIPs), and large language models (LLMs). ABSTRACT The integration of artificial intelligence (AI) into catalysis is fundamentally reshaping the research paradigm of catalyst discovery.
Di Zhang, Yuanzheng Chen, Chuanyu Liu, Yan Liu, Hongliang Xin, Jiayu Peng, Pengfei Ou, Hao Li   +7 more
wiley   +2 more sources

Friction dynamics analysis of crossed beveloid gear with considering tooth surface topography

Advances in Mechanical Engineering
The contact surfaces of beveloid gears have different topography features due to different machining methods, manufacturing accuracies, and surface wear, and they are not always smooth.
Bing Dai, Yuanwei Ding, Xuwei Li, Hancheng Mao   +3 more
doaj   +1 more source

Single‐Cell Dissection of Tumor‐Infiltrating Lymphocytes Reveals Cellular Architecture Predictive of Therapeutic Efficacy in Acral Melanoma

Advanced Science, EarlyView.
Autologous tumor‐infiltrating lymphocyte (TIL) therapy shows promising efficacy in acral melanoma, yet determinants of durable response remain unclear. By integrating single‐cell transcriptomics and TCR sequencing, this study reveals that TIL products enriched for T follicular helper and intermediate exhausted T cells establish persistent clonal ...
Chao Zhang, Wanyi Xiao, Hongru Shen, Fenge Li, Ting Li, Weihong Zhang, Haotian Liu, Ziwei Gao, Hongyu Wang, Xiubao Ren, Kexin Chen, Xiangchun Li, Jilong Yang   +12 more
wiley   +1 more source

Dynamic Behavior and Bifurcation Analysis of a Modified Reduced Lorenz Model

Mathematics
This study introduces a newly modified Lorenz model capable of demonstrating bifurcation within a specified range of parameters. The model demonstrates various bifurcation behaviors, which are depicted as distinct structures in the diagram.
Mohammed O. Al-Kaff, Ghada AlNemer, Hamdy A. El-Metwally, Abd-Elalim A. Elsadany, Elmetwally M. Elabbasy   +4 more
doaj   +1 more source

Study on the Stability and Entropy Complexity of an Energy-Saving and Emission-Reduction Model with Two Delays

Entropy, 2016
In this paper, we build a model of energy-savings and emission-reductions with two delays. In this model, it is assumed that the interaction between energy-savings and emission-reduction and that between carbon emissions and economic growth are delayed ...
Jing Wang, Yuling Wang
doaj   +1 more source

Disjoint bifurcation diagrams in combustion systems

Mathematical and Computer Modelling, 1991
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Gray, B. F., Merkin, J. H., Wake, G. C.
openaire   +2 more sources