Results 221 to 230 of about 37,406 (286)

From Classroom to Cabinet: Bridging Digital Competency and Organizational Support in Nova Scotia's Public Sector

Canadian Public Administration, EarlyView.
Abstract This research examined the relationship between digital competency and perceived organizational support among Nova Scotia public servants and MPA students. Findings revealed a non‐linear developmental progression where reliance on external validation systematically diminished as expertise matures.
Warwick Young, Kristian Suen
wiley   +1 more source

Surface optimization governs the local design of physical networks. [PDF]

Nature
Meng X, Piazza B, Both C, Barzel B, Barabási AL.   +4 more
europepmc   +1 more source

Longitudinal Analysis of Fluoride Levels in Irish Water Supplies: A 52‐Year Review

Community Dentistry and Oral Epidemiology, EarlyView.
ABSTRACT Background/Aim The Health (Fluoridation of Water Supplies) Act of 1960 in Ireland mandates monthly fluoride sampling in Public Water Supplies (PWS). In 2007, authorities adjusted the mandated fluoride concentration from 0.8–1.0 to 0.6–0.8 mg/L. Approximately 71% of the Irish population has access to fluoridated drinking water. This study aimed
Vinay Sharma, Brian O'Connell, Eithne O'Flaherty, Jan Rigby, Jacinta McLoughlin, Michael Cronin, Michael O'Sullivan, Lewis Winning, Oscar Cassetti, Michael Crowe   +9 more
wiley   +1 more source

Bifurcation study of a tumor-immune system with chemotherapy. [PDF]

PLoS One
Ajbar A, Alqahtani RT, Alhumaizi K.
europepmc   +1 more source

Multiplexed Transcriptomics for Screening Drug Combinations and Defining the Mechanism of Action of HCC Therapeutics at Single‐Cell Resolution

Cell Proliferation, EarlyView.
We designed a framework for screening clinical drug combinations with anti‐hepatocellular carcinoma (HCC) activity, comprising four parts: primary screening, single‐cell screening, functional validation, and mechanism research. High‐throughput single‐cell screening identifies HY (HHT and YM155) as a potent anti‐HCC drug combination, validated by in ...
Mengmeng Jiang, Haide Chen, Guoxia Wen, Yuqing Mei, Wenzhao Zhou, Bin Xu, Tingyue Zhang, Guangyan Li, Junqing Wu, Xiaoping Han, Xudong Fu, Guoji Guo, Jingjing Wang   +12 more
wiley   +1 more source

Persistent Homology Classifies Parameter Dependence of Patterns in Turing Systems. [PDF]

Bull Math Biol
Spector R, Harrington HA, Gaffney EA.
europepmc   +1 more source

Alternative Polyadenylation Drives Runaway Pro‐Inflammatory Macrophages in Periodontitis by Enabling Escape From miRNA Repression

Cell Proliferation, EarlyView.
APA‐Guided Therapeutic miRNA Selection for Periodontitis. ABSTRACT Periodontitis is a chronic inflammatory disease driven by a dysregulated host immune response, in which macrophage‐mediated inflammation shifts from protective to pathological. While monocyte‐derived macrophages (MDMs) are known to adopt a destructive, M1‐like pro‐inflammatory phenotype,
Jing Zhang, Yilong Zhao, Jiaru Deng, Shuyuan Qu, Yiyi Zhou, Qin Zhao, Yufeng Zhang   +6 more
wiley   +1 more source

Global dynamic characteristics of a piecewise smooth rotor/stator rubbing system with high speed. [PDF]

PLoS One
Wang S, Liu X, Liu Y, Ma J.
europepmc   +1 more source

Single‐Cell Virtual Perturbation Screening Identifies STAT3 as a Key Regulator of Dentinogenesis

Cell Proliferation, EarlyView.
STAT3 promotes odontoblast differentiation in dental mesenchymal cells by transcriptionally regulating WNT2B via the canonical Wnt/β‐catenin signalling pathway. These findings elucidate a mechanism underlying dentine development. ABSTRACT Dentine formation constitutes a physiological process precisely regulated by signal transduction modules governing ...
Yanfei Zhu, Hongyuan Xu, Zijian Zhang, Siyuan Sun, Zihan Huang, Xin Gao, Houwen Pan, Xiangru Huang, Yuanqi Liu, Xinyu Wang, Hanbin Jia, Qinggang Dai, Lingyong Jiang   +12 more
wiley   +1 more source

Investigation of a Two-Patch Within-Host Model of Hepatitis B Viral Infection. [PDF]

Bull Math Biol
Castellano S, Saucedo S, Ciupe SM.
europepmc   +1 more source