Results 61 to 70 of about 40,316 (261)

Modulation of miR‐23b Wnt/β‐catenin Axis Strengthens Endothelial Barrier Properties

Advanced Science, EarlyView.
Early blood‐brain barrier (BBB) disruption contributes to stroke and CNS disease pathology. miR‐23b was identified as a regulator of BBB integrity in brain endothelial cells. Inhibition of miR‐23b enhanced barrier‐associated properties, promoted repair‐related signaling, and reduced BBB leakage in experimental stroke models, supporting further ...
Victor Anthony Martinez, Rose E. Presby, Sara Nakanishi, Pallavi Gaur, Ugur Akcan, Johannes Daugaard Krog, Iben Daugaard Krog, Lipi Das, David S. Johnson, Danny Jamoul, Douglas Jury, Brian Lawson, Jacob Körbelin, Lewis M. Brown, Vilas Menon, Dritan Agalliu, Irene Munk Pedersen   +16 more
wiley   +1 more source

Synthetic Toll‐Like Receptors for Control of Innate Immunity With Far‐Red Light

Advanced Science, EarlyView.
Synthetic Toll‐like receptors (TLRs) are engineered by replacing their natural sensing regions with a far‐red‐light‐responsive module from a bacterial phytochrome. These synthetic receptors enable light‐controlled regulation of immune signaling in mammalian cells.
Anna V. Leopold, Vladislav V. Verkhusha
wiley   +1 more source

Single‐Cell Dissection of Therapy‐Induced Remodeling Uncovers a Fibroblast‐Driven Immunosuppressive Niche and Targetable Vulnerabilities in Lethal Prostate Cancer

Advanced Science, EarlyView.
Single‐cell longitudinal profiling reveals that androgen‐deprivation therapy induces a DPT+ fibroblast‐complement axis that suppresses macrophage inflammation and drives CD8+ T cell exhaustion in prostate cancer. Concurrently, resistant epithelial subpopulations persist and engage TSPAN1‐ and NRXN1‐mediated programs promoting CRPC and neuroendocrine ...
Yang Chen, Dandan Dong, Jinling Liao, Naikai Liao, Mengqi Liu, Qin Zhang, Siting Chen, Qi Liu, Ying Lu, Tianyu Li, Chunlin Zou, Qiong Song, Qiuyan Wang, Jian Liang, Qiji Xie, Chengyang Li, Mengyun Wang, Jiwen Cheng, Zengnan Mo, Gong‐Hong Wei   +19 more
wiley   +1 more source

CONCEPT, POSSIBILITIES AND LIMITATIONS OF SYNERGETIC METHOD IN COMPANY MANAGEMENT

Advanced Engineering Research, 2011
The matter and basic features of the synergetic method as a vitality saving tool with the simultaneous search of new development alternatives in the behavioral research on complex systems are considered.
Mikhail B. Flek, Yulia K. Verchenko
doaj  

Investigation of Early Warning Indexes in a Three-Dimensional Chaotic System with Zero Eigenvalues

Entropy, 2020
A rare three-dimensional chaotic system with all eigenvalues equal to zero is proposed, and its dynamical properties are investigated. The chaotic system has one equilibrium point at the origin.
Lianyu Chen, Fahimeh Nazarimehr, Sajad Jafari, Esteban Tlelo-Cuautle, Iqtadar Hussain   +4 more
doaj   +1 more source

Harnessing Phase Separation for the Development of High‐Performance Hydrogels

Advanced Science, EarlyView.
ABSTRACT Hydrogels are indispensable for the development of next‐generation bioelectronics, soft robotics, and biomedical devices, where their mechanical properties determine performance and reliability. Among strategies to enhance hydrogel mechanics, phase separation enables controlled heterogeneity resulting in gel networks that are reinforced by ...
Yue Shao, Yiming Ma, Baihao Shao, Molly M. Stevens   +3 more
wiley   +1 more source

CONCEPT, POSSIBILITIES AND LIMITATIONS OF SYNERGETIC METHOD IN COMPANY MANAGEMENT

Вестник Донского государственного технического университета, 2018
The matter and basic features of the synergetic method as a vitality saving tool with the simultaneous search of new development alternatives in the behavioral research on complex systems are considered.
Mikhail B. Flek, Yulia K. Verchenko
doaj  

Intervals of bifurcation points for semilinear elliptic problems

Advances in Nonlinear Analysis
In this article, we study the behavior of multiple continua of solutions to the semilinear elliptic problem −Δu=λf(u),inΩ,u=0,on∂Ω,\left\{\begin{array}{ll}-\Delta u=\lambda f\left(u),\hspace{1.0em}& \hspace{0.1em}\text{in}\hspace{0.1em}\hspace{0.33em ...
Tapia José Carmona, Aparicio Antonio J. Martínez, Martínez-Aparicio Pedro J.   +2 more
doaj   +1 more source

Beyond Electrostatics: Anion‐π+ Orbital Hybridization Underpins High‐Performance Chloride Storage in Poly(arylamine) Organic Cathodes

Advanced Science, EarlyView.
The fundamental nature of anion storage in p‐type organic cathodes is elucidated using rigid poly(arylamine) frameworks. This study reveals a hybrid covalent‐ionic mechanism for anion‐π+ interactions, driven by synergistic orbital hybridization and electrostatic attraction.
Tiantian She, Jiena Weng, Jie Wang, Qiao Xi, Yangyang Zhang, Zijie Zhang, Zongqiong Lin, Wei Huang   +7 more
wiley   +1 more source

Dielectrophoresis from the System's Point of View: A Tale of Inhomogeneous Object Polarization, Mirror Charges, High Repelling and Snap-to-Surface Forces and Complex Trajectories Featuring Bifurcation Points and Watersheds. [PDF]

Micromachines (Basel), 2022
Gimsa J, Radai MM.
europepmc   +1 more source