Results 61 to 70 of about 83,406,543 (211)

Salvianolic Acid a Disrupts the HSP90α‐AKT‐PERK Ternary Complex to Alleviate Atherosclerosis by Activating Endoplasmic Reticulum Stress of Senescent Vascular Smooth Muscle Cells

open access: yesAdvanced Science, EarlyView.
Salvianolic acid A (SAA) selectively induces senescent vascular smooth muscle cell apoptosis, alleviating atherosclerosis. Mechanistically, SAA targets heat shock protein 90 alpha (HSP90α) to disrupt the protein inase B (AKT)‐PRKR‐Like Endoplasmic Reticulum Kinase (PERK) scaffold, driving ubiquitin‐proteasome‐dependent AKT degradation.
Xiuya Guan   +8 more
wiley   +1 more source

Hydrogen‐Bonding Order Associated With Radical Delocalization in Layered Organic Cathode Materials

open access: yesAngewandte Chemie, EarlyView.
“TAQ” and TAPT share the same pyrazine‐based molecular structure but differ in degree of crystallinity. Combined x‐ray scattering, solid‐state NMR, MicroED, and EPR reveal that “TAQ”'s higher crystallinity and ordered hydrogen‐bonding network are associated with enhanced radical delocalization and conductivity, highlighting structural order as a design
Alae Eddine Lakraychi   +14 more
wiley   +2 more sources

Lower semicontinuity of attractors for non-autonomous dynamical systems [PDF]

open access: yes, 2009
This paper is concerned with the lower semicontinuity of attractors for semilinear non-autonomous differential equations in Banach spaces. We require the unperturbed attractor to be given as the union of unstable manifolds of time-dependent hyperbolic
Langa, José A.   +3 more
core   +1 more source

Remote Ischemic Post‐Conditioning Preserves the Neurovascular Unit by Brain‐Derived Gas6 That Drives Monocyte‐Derived Macrophage Reprogramming via Axl and Vimentin after SAH

open access: yesAdvanced Science, EarlyView.
Subarachnoid hemorrhage (SAH) triggers monocyte‐derived macrophage (MDM) infiltration and M1‐like polarization via Vimentin upregulation, leading to neurovascular unit disruption and cognitive dysfunction. Remote ischemic postconditioning (RIPostC) upregulates neuronal Gas6, which activates Axl on MDMs to downregulate Vimentin and drive reparative M2 ...
Yajun Zhu   +14 more
wiley   +1 more source

Analytical Prediction of Critical Transitions in Oscillator Networks With Non‐Local Links

open access: yesAdvanced Science, EarlyView.
An analytical framework reveals how global coupling, second‐harmonic strength, noise, and network structure govern oscillator‐based Ising dynamics. Spectral reduction predicts stability boundaries, while Fokker–Planck analysis captures one‐ to two‐cluster transitions and identifies conditions favoring low‐energy configurations.
Qiang Li   +5 more
wiley   +1 more source

Bifurcations of global reinjection orbits near a saddle-node Hopf bifurcation [PDF]

open access: yes, 2006
The saddle-node Hopf bifurcation (SNH) is a generic codimension-two bifurcation of equilibria of vector fields in dimension at least three. It has been identified as an organizing centre in numerous vector field models arising in applications.
Oldeman, BE   +3 more
core   +1 more source

A Hypothalamic Oxytocinergic–Sympathetic Axis Couples Anxiety Dysregulation With Impaired Tendon–Bone Repair

open access: yesAdvanced Science, EarlyView.
RCI is associated with functional suppression of oxytocinergic neurons in the PVN. Reduced PVNOXT neuronal activity contributes to altered sympathetic regulation involving the IML–sympathetic chain pathway, accompanied by changes in norepinephrine signaling at the BTI.
Liyang Wan   +8 more
wiley   +1 more source

Bifurcation and stability analysis of aircraft turning manoeuvres [PDF]

open access: yes, 2008
During ground manoeuvres a loss of lateral stability due to the saturation of the main landing gear tyres can cause the aircraft to enter a skid or a spin. The lateral stability is governed not only by aspects of the gear design, such as its geometry and
Coetzee, EB   +3 more
core  

Nonlinear Dynamics and Invariants of Motion in ReRAM Cells

open access: yesAdvanced Electronic Materials, EarlyView.
A second‐order cell, hosting one capacitor and two back‐to‐back ReRAMs, admits Invariants of Motion: its states lie on one‐dimensional manifolds at all times. The cell shows quiescent monostability or bistability, depending on the manifold index. At equilibrium, the capacitor voltage vanishes.
Mauro Di Marco   +5 more
wiley   +1 more source

Parity and generalized multiplicity [PDF]

open access: yes, 1991
Assuming that X and Y are Banach spaces and that T is a path of linear Fredholm operators with invertible endpoints, in [F-Pl] we defined a homotopy invariant "the parity of T .
Fitzpatrickp.   +2 more
core  

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